Hepatitis B incidence and prevention with antiretroviral therapy among HIV positive individuals in Rakai, Uganda

dc.contributor.authorSeremba, E.
dc.contributor.authorSsempijja, V.
dc.contributor.authorKalibbala, S.
dc.contributor.authorGray, R. H.
dc.contributor.authorWawer, M. J.
dc.contributor.authorNalugoda, F.
dc.contributor.authorCasper, C.
dc.contributor.authorPhipps, W.
dc.contributor.authorOcama, P.
dc.contributor.authorSerwadda, D.
dc.contributor.authorThomas, D. L.
dc.contributor.authorReynolds, S. J.
dc.date.accessioned2022-01-20T21:25:19Z
dc.date.available2022-01-20T21:25:19Z
dc.date.issued2017
dc.description.abstractAntiretroviral therapy (ART) may interfere with replication of hepatitis B (HBV) raising the hypothesis that HBV infection might be prevented by ART. We investigated the incidence and risk factors associated with HBV among HIV-infected adults in Rakai, Uganda. Methods—We screened stored sera from 944 HIV-infected adults enrolled in the Rakai Community Cohort Study between September 2003 and March 2015 for evidence of HBV exposure. Serum from participants who tested anti-HBc negative (497) at baseline were tested over 3-7 consecutive survey rounds for incident HBV. Poisson incidence methods were used to estimate incidence of HBV with 95% confidence intervals while Cox proportional regression methods were used to estimate hazard ratios.en_US
dc.identifier.citationSeremba, E., Ssempijja, V., Kalibbala, S., Gray, R. H., Wawer, M. J., Nalugoda, F., ... & Reynolds, S. J. (2017). Hepatitis B incidence and prevention with antiretroviral therapy among HIV positive individuals in Rakai, Uganda. AIDS (London, England), 31(6), 781. doi:10.1097/QAD.0000000000001399.en_US
dc.identifier.other10.1097/QAD.0000000000001399.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1365
dc.language.isoenen_US
dc.publisherAIDS (London, England)en_US
dc.subjectHepatitis Ben_US
dc.subjectAntiretroviral therapyen_US
dc.subjectHIV positive individualsen_US
dc.subjectRakaien_US
dc.subjectUgandaen_US
dc.titleHepatitis B incidence and prevention with antiretroviral therapy among HIV positive individuals in Rakai, Ugandaen_US
dc.typeArticleen_US
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