Hepatitis B incidence and prevention with antiretroviral therapy among HIV positive individuals in Rakai, Uganda
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
AIDS (London, England)
Abstract
Antiretroviral therapy (ART) may interfere with replication of hepatitis B (HBV) raising the hypothesis that HBV infection might be prevented by ART. We investigated the incidence and risk factors associated with HBV among HIV-infected adults in Rakai, Uganda.
Methods—We screened stored sera from 944 HIV-infected adults enrolled in the Rakai Community Cohort Study between September 2003 and March 2015 for evidence of HBV exposure. Serum from participants who tested anti-HBc negative (497) at baseline were tested over 3-7 consecutive survey rounds for incident HBV. Poisson incidence methods were used to estimate incidence of HBV with 95% confidence intervals while Cox proportional regression methods were used to estimate hazard ratios.
Description
Keywords
Hepatitis B, Antiretroviral therapy, HIV positive individuals, Rakai, Uganda
Citation
Seremba, E., Ssempijja, V., Kalibbala, S., Gray, R. H., Wawer, M. J., Nalugoda, F., ... & Reynolds, S. J. (2017). Hepatitis B incidence and prevention with antiretroviral therapy among HIV positive individuals in Rakai, Uganda. AIDS (London, England), 31(6), 781. doi:10.1097/QAD.0000000000001399.