A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks

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dc.contributor.authorMubiru, James N.
dc.contributor.authorGarcia-Forey, Magdalena
dc.contributor.authorHiggins, Paul B.
dc.contributor.authorHemmat, Peggah
dc.contributor.authorCavazos, Nicole E.
dc.contributor.authorOwston, Michael A.
dc.contributor.authorBauer, Cassondra A.
dc.contributor.authorShade, Robert E.
dc.contributor.authorComuzzie, Anthony G.
dc.contributor.authorRogers, Jeffrey
dc.date.accessioned2023-06-01T14:44:55Z
dc.date.available2023-06-01T14:44:55Z
dc.date.issued2011
dc.description.abstractThe metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition. Methods We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks. Results The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period. Conclusions Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.en_US
dc.identifier.citationMubiru, J. N., Garcia‐Forey, M., Higgins, P. B., Hemmat, P., Cavazos, N. E., Dick Jr, E. J., ... & Rogers, J. (2011). A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high‐sugar high‐fat diet for 33 weeks. Journal of medical primatology, 40(5), 335-341. doi:10.1111/j.1600-0684.2011.00495.xen_US
dc.identifier.other10.1111/j.1600-0684.2011.00495.x
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8863
dc.language.isoenen_US
dc.publisherJournal of medical primatologyen_US
dc.subjectDual X-ray absorptiometryen_US
dc.subjectInsulinen_US
dc.subjectLowdensity lipoprotein cholesterolen_US
dc.subjectTriglycerideen_US
dc.titleA preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeksen_US
dc.typeArticleen_US
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