A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of medical primatology
Abstract
The metabolic syndrome is common in populations exposed to
a typical Western diet. There is a lack of an animal model that mimics this
condition.
Methods We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat
(HSHF) diet for 33 weeks. Body weight, body composition, serum lipids,
and insulin were measured at baseline and at 33 weeks.
Results The animals tolerated the HSHF diet very well. In the intervention
group, total serum cholesterol and low-density lipoprotein cholesterol were
3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline
levels. Serum high-density lipoprotein cholesterol and triglycerides were
not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis
of the intervention group indicated that the trunk fat mass increased by
187% during this period.
Conclusions Cynomolgus monkeys should be a useful model for investigating
the interactions of diet and other factors such as genetics in the development
of the metabolic syndrome.
Description
Keywords
Dual X-ray absorptiometry, Insulin, Lowdensity lipoprotein cholesterol, Triglyceride
Citation
Mubiru, J. N., Garcia‐Forey, M., Higgins, P. B., Hemmat, P., Cavazos, N. E., Dick Jr, E. J., ... & Rogers, J. (2011). A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high‐sugar high‐fat diet for 33 weeks. Journal of medical primatology, 40(5), 335-341. doi:10.1111/j.1600-0684.2011.00495.x