Antinociceptive and anti-inflammatory activities of the methanol extract of Chlorophytum alismifolium tubers
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Traditional and Complementary Medicine
Abstract
The tubers of Chlorophytum alismifolium Baker (Family: Liliaceae) are used in Herbal Medicine for the
management of various ailments including diabetes mellitus, erectile dysfunction, abdominal pains and
inflammatory conditions. Despite its wide usage for management of pain and inflammation, there is no scientific
justification to validate this claim. This study was aimed at screening the methanol tuber extract of Chlorophytum
alismifolium for antinociceptive and anti-inflammatory activities using experimental animal models. The
antinociceptive activity was tested using acetic acid-induced writhing response in Swiss albino mice and formalininduced
pain in Wistar rats, while the anti-inflammatory activity was tested using carrageenan-induced paw edema
in rats at doses of 200, 400 and 800 mg/kg. The extract significantly (p< 0.001) reduced the number of writhes at all
tested doses. At 800 mg/kg, it significantly (p< 0.01) inhibited the first phase of formalin-induced pain while the
second phase was inhibited significantly (p< 0.05 and p< 0.01) at doses of 400 and 800 mg/kg respectively. The
extract (400 and 800 mg/kg) significantly (p< 0.05) inhibited the carrageenan-induced inflammation at the third
hour. A similar activity was also observed at the fourth hour with 61.61% inhibition of paw oedema at 400 mg/kg.
These findings suggest that Chlorophytum alismifolium tuber extract possesses antinociceptive and antiinflammatory
activities, thus support the claim for the ethnomedical use of the plant in the management of pain and
inflammatory diseases.
Description
Keywords
Chlorophytum alismifolium, Anti-nociception, Anti-inflammation, Carrageenan, Formalin
Citation
Rege, M. G., Ayanwuyi, L. O., Zezi, A. U., & Odoma, S. (2021). Anti-nociceptive, anti-inflammatory and possible mechanism of anti-nociceptive action of methanol leaf extract of Nymphaea lotus Linn (Nymphaeceae). Journal of Traditional and Complementary Medicine, 11(2), 123-129. http://dx.doi.org/10.434/jpb.v13i2.11