Pneumococcal carriage and antibiotic susceptibility patterns in mother-baby pairs in a rural community in Eastern Uganda: a cross-sectional study
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
F1000Research
Abstract
Pneumonia poses a significant threat to the lives of
children below five years old worldwide, contributing to a high
number of hospitalizations and death. Morbidity and morbidity are
especially common in children under five and the elderly, although
any age group can be affected. This study aimed to estimate
pneumococcal carriage and determine antibiotic susceptibility
patterns of the pneumococci isolated from mother-baby pairs in
Ngora district after the rollout of the pneumococcal vaccine. We
hypothesized that high carriage of Streptococcus pneumoniae in
mothers leads to carriage in their babies and hence a greater chance
of contracting pneumonia.
Methods: Consecutive sampling was used to select 152 mother-baby
pairs from community visits and those seeking care at the health
facility. We collected nasal swabs from both baby and mother for
culture and sensitivity testing using the Kirby-Bauer’s agar disc
diffusion method.
Results: This study found that there was a low prevalence of
pneumococcal carriage in the mother-baby pair in Ngora district. We
also observed high rates of microbial resistance to penicillin, which is
the first-line drug for the management of pneumonia in Uganda.
Conclusions: The relationship between pneumococcal carriage and
immunization status suggests that the pneumococcal vaccine is
protective against pneumococcal carriage. Resistance of S.
pneumoniae to commonly used antibiotics was high.
Description
Keywords
Pneumococcal carriage, Mother-baby pair, Antibiotic susceptibility pattern, Immunization with PCV 10
Citation
Akech, G. M., Naloli, M., Sebwami, P., Kazibwe, P., Atwikiriize, M., Onyait, J., ... & Iramiot, J. S. (2020). Pneumococcal carriage and antibiotic susceptibility patterns in mother-baby pairs in a rural community in Eastern Uganda: a cross-sectional study. F1000Research, 9(1156), 1156. https://doi.org/10.12688/f1000research.22238.2