Sustained heavy ethanol drinking affects CD4+ cell counts in HIV-infected patients on stavudine (d4T), lamivudine (3TC) and nevirapine (NVP) treatment regimen during 9 months follow-up period
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Date
2014
Authors
Bbosa, Godfrey S.
Kyegombe, David B.
Anokbonggo, William W.
Mugisha, Apollo
Ogwal-Okeng, Jasper
Journal Title
Journal ISSN
Volume Title
Publisher
Health
Abstract
Sustained heavy ethanol drinking is a common
problem globally and ethanol is one of the most
abused drugs among individuals of different socio-
economic status including the HIV-infected
patients on antiretroviral drugs. Ethanol is reward
drug and a CNS depressant especially at high
doses. The study determined the effect of sustained
heavy ethanol drinking by HIV-infected
patients on d4T/3TC/NVP regimen on CD4+ cell
counts in Uganda using WHO AUDIT tool and
chronic alcohol-use biomarkers. A case control
study using repeated measures design with serial
measurements model was used. The patients
on stavudine (d4T) 30 mg, lamivudine
(3TC) 150 mg and nevirapine (NVP) 200 mg and
chronic alcohol use were recruited. A total of 41
patients (20 in alcohol group and 21 in control
group) were screened for chronic alcohol use by
WHO AUDIT tool and chronic alcohol use biomarkers.
They were followed up for 9 months
with blood sampling done at 3 months intervals.
CD4+ cell count was determined using Facscalibur
Flow Cytometer system. Results were then
sorted by alcohol-use biomarkers (GGT, MCV
and AST/ ALT ratio). Data were analysed using
SAS 2003 version 9.1 statistical package with
repeated measures fixed model and the means
were compared using student t-test. The mean
CD4+ cell counts in all the groups were lower than
the reference ranges at baseline and gradually
increased at 3, 6 and 9 months of follow-up. The
mean CD4+ cell counts were higher in the control
group as compared to the chronic alcohol
use group in both WHO AUDIT tool group and
chronic alcohol-use biomarkers group though
there was no significant difference (p > 0.05).
Chronic alcohol use slightly lowers CD4+ cell
count in HIV-infected patients on d4T/3TC/NVP
treatment regimen.
Description
Keywords
Sustained Heavy Ethanol Drinking, CD4+ Cell Counts, HIV-Infected Patients, d4T/3TC/NVP Drug Regimen
Citation
Bbosa, GS, Kyegombe, DB, Anokbonggo, WW, Mugisha, A., & Ogwal-Okeng, J. (2014). Sustained heavy ethanol drinking affects CD4+ cell counts in HIV-infected patients on stavudine (d4T), lamivudine (3TC) and nevirapine (NVP) treatment regimen during 9 months follow-up period. Health , 2014 . http://dx.doi.org/10.4236/health.2014.65061