Pneumococcal Carriage in Children under Five Years in Uganda- Will Present Pneumococcal Conjugate Vaccines Be Appropriate?
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
PLoS ONE
Abstract
Pneumonia is the major cause of death in children globally, with more than 900,000 deaths
annually in children under five years of age. Streptococcus pneumoniae causes most
deaths, most often in the form of community acquired pneumonia. Pneumococcal conjugate
vaccines (PCVs) are currently being implemented in many low-income countries. PCVs
decrease vaccine-type pneumococcal carriage, a prerequisite for invasive pneumococcal
disease, and thereby affects pneumococcal disease and transmission. In Uganda,
PCV was launched in 2014, but baseline data is lacking for pneumococcal serotypes in
carriage.
Objectives
To study pneumococcal nasopharyngeal carriage and serotype distribution in children
under 5 years of age prior to PCV introduction in Uganda
Methods
Three cross-sectional pneumococcal carriage surveys were conducted in 2008, 2009 and
2011, comprising respectively 150, 587 and 1024 randomly selected children aged less
than five years from the Iganga/Mayuge Health and Demographic Surveillance Site. The
caretakers were interviewed about illness history of the child and 1723 nasopharyngeal
specimens were collected. From these, 927 isolates of S. pneumoniae were serotyped.
Description
Keywords
Pneumococcal Carriage, Children, Uganda, Pneumococcal Conjugate Vaccines
Citation
Lindstrand A, Kalyango J, AlfveÂn T, Darenberg J, Kadobera D, Bwanga F, et al. (2016) Pneumococcal Carriage in Children under Five Years in Uganda±Will Present Pneumococcal Conjugate Vaccines Be Appropriate? PLoS ONE 11 (11): e0166018. doi:10.1371/journal. pone.0166018