Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from east Africa suggests two independent introductions from southern Africa
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
BMC evolutionary biology,
Abstract
In East Africa, foot-and-mouth disease virus serotype SAT 1 is responsible for occasional severe
outbreaks in livestock and is known to be maintained within the buffalo populations. Little is known about the
evolutionary forces underlying its epidemiology in the region. To enhance our appreciation of the epidemiological
status of serotype SAT 1 virus in the region, we inferred its evolutionary and phylogeographic history by means of
genealogy-based coalescent methods using 53 VP1 coding sequences covering a sampling period from 1948-2007.
Results: The VP1 coding sequence of 11 serotype SAT 1 FMD viruses from East Africa has been determined and
compared with known sequences derived from other SAT 1 viruses from sub-Saharan Africa. Purifying (negative)
selection and low substitution rates characterized the SAT 1 virus isolates in East Africa. Two virus groups with
probable independent introductions from southern Africa were identified from a maximum clade credibility tree.
One group was exclusive to Uganda while the other was present within Kenya and Tanzania.
Conclusions: Our results provide a baseline characterization of the inter-regional spread of SAT 1 in sub-Saharan
Africa and highlight the importance of a regional approach to trans-boundary animal disease control in order to
monitor circulating strains and apply appropriate vaccines.
Description
Keywords
foot-and-mouth disease, virus serotype SAT 1
Citation
Sangula, A. K., Belsham, G. J., Muwanika, V. B., Heller, R., Balinda, S. N., Masembe, C., & Siegismund, H. R. (2010). Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from east Africa suggests two independent introductions from southern Africa. BMC evolutionary biology, 10(1), 1-8.