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    Severe COVID-19 in Uganda across Two Epidemic Phases: A Prospective Cohort Study

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    Severe COVID-19 in Uganda across Two Epidemic Phases A Prospective Cohort Study (579.6Kb)
    Date
    2021
    Author
    Bakamutumaho, Barnabas
    Cummings, Matthew J.
    Owor, Nicholas
    Kayiwa, John
    Namulondo, Joyce
    Byaruhanga, Timothy
    Muwanga, Moses
    Nsereko, Christopher
    Mutonyi, Roselyn
    Achan, Josephine
    wanyenze, Lucy
    Ndazarwe, Alice
    Nakanjako, Ruth
    Natuhwera, Richard
    Nsangi, Annet
    Bosa, Henry Kyobe
    Ocom, Felix
    Kikaire, Bernard
    Lutwama, Julius J.
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    Abstract
    Among a prospective cohort of children and adults admitted to a national COVID-19 treatment unit in Uganda from March to December 2020, we characterized the epidemiology of and risk factors for severe illness. Across two epidemic phases differentiated by varying levels of community transmission, the proportion of patients admitted with WHO-defined severe COVID-19 ranged from 5% (7/146; 95% CI: 2–10) to 33% (41/124; 95% CI: 25–42); 21% (26/124; 95% CI: 14–29%) of patients admitted during the peak phase received oxygen therapy. Severe COVID-19 was associated with older age, male sex, and longer duration of illness before admission. Coinfection with HIV was not associated with illness severity; malaria or tuberculosis coinfection was rare. No patients died during admission. Despite low mortality, hospital incidence of severe COVID-19 during the first epidemic peak in Uganda was substantial. Improvements in vaccine deployment and acute care capacity, including oxygen delivery, are urgently needed to prevent and manage severe COVID-19 in sub-Saharan Africa.
    URI
    https://nru.uncst.go.ug/handle/123456789/3252
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    • Medical and Health Sciences [2957]

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