High Frequency of False-Positive Hepatitis C Virus Enzyme-Linked Immunosorbent Assay in Rakai, Uganda
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Clinical infectious diseases
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The prevalence of hepatitis C virus (HCV) infection in subSaharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) participants were HCV antibody positive; none were confirmed by detection of HCV RNA.
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Mullis, C. E., Laeyendecker, O., Reynolds, S. J., Ocama, P., Quinn, J., Boaz, I., ... & Stabinski, L. (2013). High frequency of false-positive hepatitis C virus enzyme-linked immunosorbent assay in Rakai, Uganda. Clinical infectious diseases, 57(12), 1747-1750. DOI: 10.1093/cid/cit602