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    Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy

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    Article (442.6Kb)
    Date
    2018
    Author
    Makanani, Bonus
    Balkus, Jennifer E.
    Jiao, Yuqing
    Noguchi, Lisa M.
    Palanee-Phillips, Thesla
    Mbilizi, Yamikani
    Moodley, Jothi
    Kintu, Kenneth
    Reddy, Krishnaveni
    Kabwigu, Samuel
    Jeenariain, Nitesha
    Harkoo, Ishana
    Mgodi, Nyaradzo
    Piper, Jeanna
    Rees, Helen
    Scheckter, Rachel
    Beigi, Richard
    Baeten, Jared M. ,
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    Abstract
    Monthly use of the dapivirine vaginal ring has been shown to be safe and effective for HIV-1 prevention in nonpregnant reproductive-aged women. The impact of dapivirine on pregnancy outcomes and infant is not known. We compared pregnancy incidence and outcomes by study arm among HIV-1–uninfected women who became pregnant while participating in MTN-020/ASPIRE. ASPIRE was a randomized, double-blind, placebocontrolled phase III safety and effectiveness study of the dapivirinering for HIV-1 prevention. Sexually active women aged 18–45 years from Malawi, South Africa, Uganda, and Zimbabwe were enrolled. Urine pregnancy tests were performed monthly, and, if positive, study product was withheld during pregnancy and breastfeeding. Pregnancy-related outcomes included the following: pregnancy incidence, pregnancy outcomes (live birth, preterm birth, pregnancy loss, and congenital anomalies), and infant growth.
    URI
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231990/
    https://nru.uncst.go.ug/xmlui/handle/123456789/1434
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