Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy

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dc.contributor.authorMakanani, Bonus
dc.contributor.authorBalkus, Jennifer E.
dc.contributor.authorJiao, Yuqing
dc.contributor.authorNoguchi, Lisa M.
dc.contributor.authorPalanee-Phillips, Thesla
dc.contributor.authorMbilizi, Yamikani
dc.contributor.authorMoodley, Jothi
dc.contributor.authorKintu, Kenneth
dc.contributor.authorReddy, Krishnaveni
dc.contributor.authorKabwigu, Samuel
dc.contributor.authorJeenariain, Nitesha
dc.contributor.authorHarkoo, Ishana
dc.contributor.authorMgodi, Nyaradzo
dc.contributor.authorPiper, Jeanna
dc.contributor.authorRees, Helen
dc.contributor.authorScheckter, Rachel
dc.contributor.authorBeigi, Richard
dc.contributor.authorBaeten, Jared M. ,
dc.date.accessioned2022-01-22T19:43:35Z
dc.date.available2022-01-22T19:43:35Z
dc.date.issued2018
dc.description.abstractMonthly use of the dapivirine vaginal ring has been shown to be safe and effective for HIV-1 prevention in nonpregnant reproductive-aged women. The impact of dapivirine on pregnancy outcomes and infant is not known. We compared pregnancy incidence and outcomes by study arm among HIV-1–uninfected women who became pregnant while participating in MTN-020/ASPIRE. ASPIRE was a randomized, double-blind, placebocontrolled phase III safety and effectiveness study of the dapivirinering for HIV-1 prevention. Sexually active women aged 18–45 years from Malawi, South Africa, Uganda, and Zimbabwe were enrolled. Urine pregnancy tests were performed monthly, and, if positive, study product was withheld during pregnancy and breastfeeding. Pregnancy-related outcomes included the following: pregnancy incidence, pregnancy outcomes (live birth, preterm birth, pregnancy loss, and congenital anomalies), and infant growth.en_US
dc.identifier.citationMakanani, B., Balkus, J. E., Jiao, Y., Noguchi, L. M., Palanee-Phillips, T., Mbilizi, Y., ... & Baeten, J. M. (2018). Pregnancy and infant outcomes among women using the dapivirine vaginal ring in early pregnancy. Journal of acquired immune deficiency syndromes (1999), 79(5), 566.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231990/
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1434
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectDapivirineen_US
dc.subjectPregnancyen_US
dc.subjectHIV preventionen_US
dc.subjectWomenen_US
dc.subjectAfricaen_US
dc.titlePregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancyen_US
dc.typeArticleen_US
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