Early maternal separation leads to down-regulation of cytokine gene expression
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Date
2012-04-13
Journal Title
Journal ISSN
Volume Title
Publisher
Metabolic brain disease
Abstract
Exposure to stressors may lead to subsequent
alterations in the immune response. The precise mechanisms
underlying such vulnerability are poorly understood, but
may be hypothesized to include changes in cytokine systems.
Maternal separation was used as a model of exposure
to early life stressors. Subsequent cytokine gene expression
was studied using a cytokine gene expression array. Maternal
separation resulted in significant down-regulation of the
expression of 6 cytokine genes; chemokine ligand 7, chemokine
receptor 4, interleukin 10, interleukin-1beta, interleukin
5 receptor alpha and integrin alpha M. Specific cytokines
may be involved in mediating the effects of early adversity
on subsequent immunosuppression. Further work is needed
to delineate fully the relationship between early adversity,
immune alterations, and behavioural changes.
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Citation
Dimatelis, J. J., Pillay, N. S., Mutyaba, A. K., Russell, V. A., Daniels, W. M. U., & Stein, D. J. (2012). Early maternal separation leads to down-regulation of cytokine gene expression. Metabolic brain disease, 27(3), 393-397.