Browsing by Author "Van Wie, B. J."

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    Neuron-based sensors for biochemical quantitation
    (Proceedings of the Annual International Engineering in Medicine and Biology Society, 1989) Kisaalita, William S.; Skeen, R.S.; Van Wie, B. J.; Barnes, C. D.; Fung, S. J.; Davis, W. C.
    Using intracellular recording from freshly dissected Limnea stagnalis neurons and cultured clones for mouse neuroblastoma, N-18 and N1E-115, linear relationships between several analyte concentrations and neuron electrical properties, such as action potential, are obtained. This demonstrates the suitability of neurons as primary transducers in neuron-based sensors. Initial development work that will lead to testing cultured neurons for the detection of monoclonal antibodies is reported.<>