Browsing by Author "Tamale Ssekitoleko, Robert"

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    Green synthesis and characterization of iron‑oxide nanoparticles using Moringa oleifera: a potential protocol for use in low and middle income countries
    (BMC Research Notes, 2022) Kiwumulo, Henry Fenekansi; Muwonge, Haruna; Ibingira, Charles; Lubwama, Michael; Kirabira, John Baptist; Tamale Ssekitoleko, Robert
    Green synthesized iron(III) oxide ( Fe3O4) nanoparticles are gaining appeal in targeted drug delivery systems because of their low cost, fast processing and nontoxicity. However, there is no known research work undertaken in the production of green synthesized nano-particles from the Ugandan grown Moringa Oleifera (MO). This study aims at exploring and developing an optimized protocol aimed at producing such nanoparticles from the Ugandan grown Moringa. Results: While reducing ferric chloride solution with Moringa oleifera leaves, Iron oxide nanoparticles ( Fe3O4-NPs) were synthesized through an economical and completely green biosynthetic method. The structural properties of these Fe3O4- NPs were investigated by Ultra Violet–visible (UV–Vis) spectrophotometry, X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM). These nanoparticles exhibited UV–visible absorption peaks at 225 nm (nm) for the sixth dilution and 228 nm for the fifth dilution which indicated that the nanoparticles were photosensitive and the SEM study confirmed the spherical nature of these nanoparticles. The total synthesis time was approximately 5 h after drying the moringa leaves, and the average particle size was approximately 16 nm. Such synthesized nanoparticles can potentially be useful for drug delivery, especially in Low and Middle Income Countries (LMICs).
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    The Status of Medical Devices and their Utilization in 9 Tertiary Hospitals and 5 Research Institutions in Uganda
    (Global Clinical Engineering Journal, 2021) Tamale Ssekitoleko, Robert; Ngabirano Arinda, Beryl; Oshabahebwa, Solomon; Namuli, Lucy Kevin; Mugaga, Julius; Namayega, Catherine; Einyat Opolot, Emmanuel; Baluka, Jackline; Ibingira, Charles; Munabi, Ian Guyton; Lutakome Joloba, Moses
    Advancements in technology have led to great strides in research and innovation that have improved healthcare provision around the world. However, the majority of the technology available is underutilized in Sub- Saharan Africa. In addition, the ever-increasing sophistication and cost of medical equipment means that access and proper use is limited in low- and middle-income countries (LMICs). There is, however, a general paucity of well-documented evidence for the utilization of medical equipment in LMICs. Therefore, this study evaluates the current availability and utilization of medical equipment in tertiary hospitals and research facilities in Uganda and provides baseline information to clinical/biomedical engineers, innovators, managers, and policymakers.
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    A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
    (Mathematical Biosciences and Engineering, 2021) Fenekansi Kiwumulo, Henry; Muwonge, Haruna; Ibingira, Charles; Kirabira, John Baptist; Tamale Ssekitoleko, Robert
    Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised to aid planning before a specific treatment is administered. In such approaches, precise treatment, as it is the case in radiotherapy, is used to administer a maximum dose to the infected regions while minimizing the effect on normal tissue. Complicated cancers such as leukemia present even greater challenges due to their presentation in liquid form and not being localised in one area. As such, science has led to the development of targeted drug delivery, where the infected cells can be specifically targeted anywhere in the body.