Browsing by Author "Seeleya, Janet"

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    Experiences of research ethics committee members and scientists of the research protocol review process in Uganda: a case study
    (International Health, 2020) Ssali, Agnes; Poland, Fiona; Seeleya, Janet
    We investigated how relevant and responsive scientists and research ethics committee (REC) members considered the research protocol review processes for health research practice in Uganda. Methods: Interviews were conducted with five scientists and five REC members. Data were analysed thematically. Results: How much to compensate for time, the amount of study information shared with volunteers and sample storage for future unknown research were areas of concern for REC members. Delays in getting feedback concerned scientists. Conclusions: Researchers and REC members need to hold regular discussions to ensure the review process is relevant and responsive.
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    Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda
    (Contemporary clinical trials communications, 2017) Ssali, Agnes; Nunn, Andrew; Mbonyea, Martin; Anywainea, Zacchaeus; Seeleya, Janet
    Introduction: The reasons why research participants join clinical trials remains an area of inquiry especially in low and middle income countries. Methods: We conducted exit interviews with participants who took part in a trial which aimed to evaluate whether long term prophylaxis with cotrimoxazole can be safely discontinued among adults who have been stabilised on antiretroviral therapy (ART). Participants were all reported to be stable on ART and had been participating in the trial for between 12 and 36 months; at the end of the trial participants were interviewed using a semi-structured questionnaire. One of the objectives of the exit interview was to find out what motivated the participants to join the research. Results: Participants gave personal reasons for joining the trial, frequently linked to their health and well-being as well as reduction of pill burden. Conclusion: We conclude that underlying reasons for joining clinical trials may extend beyond or can be different from the rationale given to the participants before enrolment by the research team. The reasons that motivate enrolment to clinical trials and research in general require further investigation in different settings. Trial registration number: ISRCTN44723643.