Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Contemporary clinical trials communications
Abstract
Introduction: The reasons why research participants join clinical trials remains an area of inquiry especially in
low and middle income countries.
Methods: We conducted exit interviews with participants who took part in a trial which aimed to evaluate
whether long term prophylaxis with cotrimoxazole can be safely discontinued among adults who have been
stabilised on antiretroviral therapy (ART). Participants were all reported to be stable on ART and had been
participating in the trial for between 12 and 36 months; at the end of the trial participants were interviewed
using a semi-structured questionnaire. One of the objectives of the exit interview was to find out what motivated
the participants to join the research.
Results: Participants gave personal reasons for joining the trial, frequently linked to their health and well-being
as well as reduction of pill burden.
Conclusion: We conclude that underlying reasons for joining clinical trials may extend beyond or can be different
from the rationale given to the participants before enrolment by the research team. The reasons that motivate
enrolment to clinical trials and research in general require further investigation in different settings.
Trial registration number: ISRCTN44723643.
Description
Keywords
Randomised clinical trials, Volunteers, Participants
Citation
Ssali, A., Nunn, A., Mbonye, M., Anywaine, Z., & Seeley, J. (2017). Reasons for participating in a randomised clinical trial: the volunteers' voices in the COSTOP trial in Uganda. Contemporary clinical trials communications, 7, 44-47.http:// dx.doi.org/10.1016/j.conctc.2017.05.007