Browsing by Author "Munabi, Ian Guyton"

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    A comparison of oral bacteriome isolated from periodontal pockets of participants with or without diabetes mellitus in Uganda: a case control study
    (BioMed Central Ltd, 2024-05) Kiryowa, Haruna Muhmood; Buwembo, William; Munabi, Ian Guyton; Mwaka, Erisa Sabakaki; Rwenyonyi, Charles Mugisha; Kaddumukasa, Mark; Kiguli, Sarah
    Abstract Objective Diabetes mellitus predisposes patients to increased incidence and severe forms of periodontal disease. Currently, information on the bacterial diversity of patients with diabetes mellitus and periodontitis in Uganda is scanty. This study set out to describe the bacteria associated with periodontitis in patients with diabetes mellitus in Uganda, as part of a larger study describing the association between periodontal disease and diabetes mellitus. Results This was a case control involving 45 samples of gingival crevicular fluid collected from participants with periodontitis, the cases being 26 participants with diabetes mellitus and controls 19 participants without diabetes mellitus. Sequencing using the 16s Oxford nanopore long read protocol was followed by a bioinformatics analysis pipeline for alpha and beta diversity indices in the two groups. Multivariate tests were done to determine the differences in the bacterial composition in the two groups. Of the 739 Operational Taxonomic Units and 500 phyla identified, 37.9% (280/739) were from participants with diabetes mellitus. Analysis of beta diversity revealed a dissimilarity between the two study groups (CAP score=0) with a significant association noted between periodontitis and the subgingival bacteria (P=0.001). Diabetes mellitus reduced the quantity and altered the composition of the subgingival microbiome in the study participants. Keywords Diabetes mellitus, Microbiome, OTUs, Periodontal pockets and periodontitis
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    Low Bone Mass In People Living With HIV On Long-Term Anti-Retroviral Therapy: A Single Center Study In Uganda
    (PloS one, 2021) Mwaka, Erisa Sabakaki; Munabi, Ian Guyton; Castelnuovo, Barbara; Kaimal, Arvind; Kasozi, William; Kambugu, Andrew; Musoke, Philippa; Katabira, Elly
    This study set out to determine the prevalence of low bone mass following long-term exposure to antiretroviral therapy in Ugandan people living with HIV.A cross-sectional study was conducted among 199 people living with HIV that had been on anti-retroviral therapy for at least 10 years. All participants had dual X-ray absorptiometry to determine their bone mineral density. The data collected included antiretroviral drug history and behavioral risk data Descriptive statistics were used to summarize the data. Inferential statistics were analyzed using multilevel binomial longitudinal Markov chain Monte Carlo mixed multivariate regression modelling using the rstanarm package.One hundred ninety nine adults were enrolled with equal representation of males and females. The mean age was 39.5 (SD 8.5) years. Mean durations on anti-retroviral treatment was 12.1 (SD 1.44) years, CD4 cell count was 563.9 cells/mm3. 178 (89.5%) had viral suppression with <50 viral copies/ml. There were 4 (2.0%) and 36 (18%) participants with low bone mass of the hip and lumbar spine respectively. Each unit increase in body mass index was associated with a significant reduction in the odds for low bone mineral density of the hip and lumbar spine. The duration on and exposure to the various antiretroviral medications had no significant effect on the participant’s odds for developing low bone mass. All the coefficients of the variables in a multivariable model for either hip or lumbar spine bone mass were not significant.These results provide additional evidence that patients on long term ART achieve bone mass stabilization. Maintaining adequate body weight is important in maintaining good bone health in people on antiretroviral therapy.
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    A Mixed Methods Approach To Prioritizing Components Of Uganda’s ehealth Environment
    (Pan African Medical Journal, 2015) Mukooyo, Eddie Sefululya; Lutwama, Andrew; Munabi, Ian Guyton; Sewankambo, Nelson; Aceng, Ruth Jane
    Globally the use of information and communication technologies (ICTs) in healthcare, eHealth, is on the increase. This increased use is accompanied with several challenges requiring uniformly understood and accepted regulations. Developing such regulations requires the engagement of all stakeholders. In this manuscript we explored the priorities of various eHealth stakeholders in Uganda to inform the eHealth policy review process.
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    Relationship between maternal pelvis height and other anthropometric measurements in a multisite cohort of Ugandan mothers
    (Pan African Medical Journal, 2016) Munabi, Ian Guyton; Byamugisha, Josaphat; Luboobi, Livingstone; Abilemech Luboga, Samuel; Mirembe, Florence
    In sub Saharan Africa, childbirth remains a challenge that creates the need for additional screening tools. Maternal pelvis height, which is currently in use by automotive engineers has previously been shown to have significant associations with various childbirth related outcomes and events. This study set out to determine the associations between maternal: Age, height, weight and number of pregnancies with maternal pelvis height in Ugandan mothers. Methods: This was a secondary analysis of maternal birth records from nine Ugandan hospitals, of mothers with singleton pregnancies. Data was analyzed using multilevel regression with respect to maternal pelvis height and additional analysis for tribe and site of childbirth intraclass correlations (ICCs). Results: The mean maternal pelvis height was 7.30cm for the 2068 records. Maternal pelvis height was associated with: a 0.01cm reduction per centimeter of maternal height (P=0.02), 0.01cm increase per kg of maternal weight (P<0.01), 0.04cm increase for each additional pregnancy (P=0.03) and 0.03cm increase with respect to tribe of mother (P=0.27), for a constant of 7.97cm (P<0.01). The ICC for tribe was 0.20 (SE=0.08) and 0.37 (SE=0.11) for site. Conclusion: Maternal pelvis height was associated with maternal height, maternal weight and number of pregnancies. The site of childbirth had a moderate effect on the above associations with maternal pelvis height. More study on the public health screening value of these measurements in these settings is required.
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    The Status of Medical Devices and their Utilization in 9 Tertiary Hospitals and 5 Research Institutions in Uganda
    (Global Clinical Engineering Journal, 2021) Tamale Ssekitoleko, Robert; Ngabirano Arinda, Beryl; Oshabahebwa, Solomon; Namuli, Lucy Kevin; Mugaga, Julius; Namayega, Catherine; Einyat Opolot, Emmanuel; Baluka, Jackline; Ibingira, Charles; Munabi, Ian Guyton; Lutakome Joloba, Moses
    Advancements in technology have led to great strides in research and innovation that have improved healthcare provision around the world. However, the majority of the technology available is underutilized in Sub- Saharan Africa. In addition, the ever-increasing sophistication and cost of medical equipment means that access and proper use is limited in low- and middle-income countries (LMICs). There is, however, a general paucity of well-documented evidence for the utilization of medical equipment in LMICs. Therefore, this study evaluates the current availability and utilization of medical equipment in tertiary hospitals and research facilities in Uganda and provides baseline information to clinical/biomedical engineers, innovators, managers, and policymakers.