Browsing by Author "Mugyenyi, Godfrey R."

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    Occurrence Of Anti-D Alloantibodies Among Pregnant Women In Kasese District, Western Uganda
    (Journal of blood medicine, 2015) Mbalibulha, Yona; Muwanguzi, Enoch; Mugyenyi, Godfrey R.; Natukunda, Bernard
    This study was undertaken to determine the distribution of ABO/RhD (rhesus D antigen) blood phenotypes, prevalence of anti-D alloantibodies, and the risk factors for alloimmunization among pregnant women in Kasese District, Western Uganda. Ethylenediamine tetraacetic acid-containing plasma samples and serum samples were taken from pregnant women attending the antenatal clinic. The blood groups were identified using the microplate grouping method, while the presence of anti-D alloantibodies was detected by the indirect antiglobulin test (IAT). Data were also collected from the pregnant women on the risk factors associated with anti-D alloantibody formation.Among the 726 participants, the blood group distribution was as follows: O: 356 (49.%); A: 190 (26.%); B: 152 (21%); and AB: 28 (4%). A total of 28 (3.86%) pregnant women were RhD negative. Anti-D alloantibodies were detected in 88 (12.1%) of the participants; and of these, 13 (14.8%) were RhD negative. Statistically significant risk factors for anti-D alloimmunization included miscarriage, stillbirth, and postpartum hemorrhage.Blood group O was the most common among the pregnant women in this study and the prevalence of Rh negativity was 3.8%. The frequency of anti-D alloimmunization among pregnant women in Kasese District was 12.12%, with 85.5% of these being RhD positive. Risk factors such as a history of stillbirths, miscarriages, and incidence of postpartum hemorrhage were significantly associated with anti-D alloimmunization. There is a need to routinely carry out antenatal blood grouping and IAT screening on pregnant women in Uganda to detect anti-D alloimmunization. Given the high prevalence of anti-D alloantibody formation among RhD-positive women, we recommend additional research studies on the role of autoimmunity among antigen-positive women, as well as the occurrence of RhD variants plus their implications on hemolytic disease of the fetus and newborn, in Uganda.
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    Prevalence of Ethanol Use Among Pregnant Women in Southwestern Uganda
    (Women health journal, 2016) English, Lacey; Mugyenyi, Godfrey R.; Ngonzi, Joseph; Kiwanuka, Gertrude; Nightingale, Ira; Koren, Gideon; MacLeod, Stuart; Grunau, Brian E.; Wiens, Matthew O. ,
    The prevalence of ethanol use in many Sub-Saharan African countries is high and reported to be increasing among women. Some areas of Sub-Saharan African, such as regions of South Africa, have high rates of fetal alcohol spectrum disorder (FASD), but few data exist for other countries. The potential social and economic consequences of alcohol-exposed pregnancies are significant. The objective of this study was to determine the prevalence and predictors of ethanol use among women delivering at a regional hospital in Southwestern Uganda.
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    Sublingual Misoprostol versus Intramuscular Oxytocin for Prevention of Postpartum Hemorrhage in Uganda: A Double-Blind Randomized Non-Inferiority Trial
    (PLoS medicine, 2014-11-04) Atukunda, Esther C.; Obua, Celestino; Mugyenyi, Godfrey R.; Twagirumukiza, Marc; Agaba, Amon G.
    Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lack of data about the comparative efficacy of oxytocin and sublingual misoprostol, particularly at the recommended dose of 600 µg, for prevention of PPH during active management of labor.
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    When women deliver at home with no one present: Are health care systems in Uganda driving women away?
    (Research Square, 2019) Atukunda, Esther Cathyln; Mugyenyi, Godfrey R.; Obua, Celestino; Najjuma, Josephine; Aturinda, Isaac; Agaba, Edgar; Ware, Norma C.; Matthews, Lynn T.
    Uganda’s maternal mortality remains unacceptably high, with thousands of women and newborns still dying of preventable deaths from pregnancy and childbirth-related complications. Despite the fact that over 95% of women in Uganda attend at least one antenatal care (ANC) visit, over 30% of women still deliver at home with no skilled birth attendant, many choosing to come to hospital after experiencing a complication. We explored barriers to women’s decisions to deliver in a health care facility among postpartum women in rural southwestern Uganda, to ultimately inform interventions aimed at improving skilled facility births.