Browsing by Author "Becker, Marissa L."

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    Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission
    (New England Journal of Medicine, 2008) Damme, Lut Van; Govinden, Roshini; Mirembe, Florence M.; Guédou, Fernand; Solomon, Suniti; Becker, Marissa L.; Pradeep, B.S.; Krishnan, A.K.; Alary, Michel; Pande, Bina; Ramjee, Gita; Deese, Jennifer; Crucitti, Tania; Taylor, Doug
    Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed. Methods We performed a randomized, double-blind, placebo-controlled trial of cellulose sulfate, an HIV-entry inhibitor formulated as a vaginal gel, involving women at high risk for HIV infection at three African and two Indian sites. The primary end point was newly acquired infection with HIV type 1 or 2. The secondary end point was newly acquired gonococcal or chlamydial infection. The primary analysis was based on a log-rank test of no difference in the distribution of time to HIV infection, stratified according to site.