Browsing by Author "Akello, Carolyne A."

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    Impact of DSMB Outcomes on Participation in HIV Prevention Trials: The VOICE Study Experience in Kampala, Uganda
    (AIDS Research and Human Retroviruses, 2014) Etima, Juliane; Nakyanzi, Teopista; Kabwigu, Samuel; Kiweewa, Flavia M.; Mirembe, Brenda G.; Akello, Carolyne A.; Rossi, Lisa; Nakabiito, Clemensia
    Clinical trials are monitored and regulated by independent bodies to ensure participants’ safety and ethical conduct. Depending on study progress, these bodies may recommend a trial to continue as is, be modified or stopped. Six such reviews were conducted during the implementation of the VOICE study. We describe the impact of Data & Safety Monitoring Board (DSMB) recommendations on continued study participation in Kampala, Uganda, including retention, researchers’ motivation to continue the study, and community perceptions and attitudes about the study.