Impact of DSMB Outcomes on Participation in HIV Prevention Trials: The VOICE Study Experience in Kampala, Uganda
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
AIDS Research and Human Retroviruses
Abstract
Clinical trials are monitored and regulated by
independent bodies to ensure participants’ safety and ethical
conduct. Depending on study progress, these bodies may recommend
a trial to continue as is, be modified or stopped. Six
such reviews were conducted during the implementation of the
VOICE study. We describe the impact of Data & Safety Monitoring
Board (DSMB) recommendations on continued study
participation in Kampala, Uganda, including retention, researchers’
motivation to continue the study, and community
perceptions and attitudes about the study.
Description
Keywords
DSMB Outcomes, Participation, HIV, Uganda
Citation
Etima, J., Nakyanzi, T., Kabwigu, S., Kiweewa, F. M., Mirembe, B. G., Akello, C. A., ... & Nakabiito, C. (2014). Impact of DSMB Outcomes on Participation in HIV Prevention Trials: The VOICE Study Experience in Kampala, Uganda. AIDS Research and Human Retroviruses, 30(S1), A251-A251.