The National Research Repository of Uganda - NRU

Welcome to the National Research Repository of Uganda, abbreviated as "NRU". NRU was established in 2021. NRU is a collection of scholarly output by researchers from the UNCST Community, including scholarly articles and books, electronic theses and dissertations, conference proceedings, journals, technical reports and digitised library collections. It is the official Institutional Archive (IA) of UNCST.

Copyright Information:

For information about the publishers' copyright policy on archiving your articles online or in an institutional archive, visit the Sherpa Site at http://www.sherpa.ac.uk/romeo.php The site gives a summary of the permissions normally given as part of each publisher's copyright transfer agreement. If you wish to publish your research findings in the NRU, please contact NRU administrator at admin@uncst.go.ug for details. NRU operates both open access and closed access models. Access to fulltext has been restricted in adherence to the UNCST Intellectual Property Rights (IPR) and Copyrights policies.

Other Useful Resources:

Africa Portal is an online repository of open access library collection with over 3,000 books, journals, and digital documents on African policy issues. This is an initiative by the Centre for International Governance Innovation (CIGI), Makerere University (MAK), and the South African Institute of International Affairs (SAIIA). Please visit the Africa Portal at http://www.africaportal.org/library.

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Recent Submissions

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Acceptability of study procedures (self‑collected introital swabs, blood draws and stool sample collection) by students 10–16 years for an HPV vaccine effectiveness study: a pilot study
(BMC Research Notes, 2016-03-16) Nakalembe, Miriam; Mutyaba, Twaha; Mirembe, Florence
A cohort study was planned to evaluate vaccine immunogenicity and effect of malaria and helminth co-infections on the bivalent Human papilloma virus (HPV) vaccine. The study would involve self collected introital swabs, blood draws and stool sample collection. We therefore conducted a pilot study to assess the acceptability of these procedures among the students and their parents. A cross-sectional study among forty four students from two purposively selected primary schools of Western Uganda. Exit interviews and two focus group discussions (FGD) (for parents) were conducted. Acceptability was measured by willingness to undergo the procedures again, recommending the procedures to others as well as proportion of introital swabs positive for β globulin. FGD determined acceptability of the parents and explored opinions and perceptions that would influence their decisions. HPV-16/18 and β globulin deoxyribonucleic acid (DNA) were analysed using a polymerase chain reaction (PCR) kit. All the students (100 %) in the study were willing to provide a self- collected introital swab and a stool sample as well as recommending their friends while (86.3 %) were willing for blood draws. There were 40/44 (90.1 %) self collected introital swabs that had positive result for human β globulin though none of them was positive for HPV-16/18. In the FGD, it emerged that parents concerns were on the blood draws and introital swab collection which were addressed. The study procedures were highly acceptable among this study population of students and their parents. Follow-up to assess HPV vaccine effectiveness and factors that may influence the vaccine in this age group is feasible.
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Remote Ischaemic Conditioning in STEMI Patients in Sub-Saharan AFRICA: Rationale and Study Design for the RIC-AFRICA Trial
(Cardiovascular Drugs and Therapy, 2021-11-05) Lukhna, Kishal; Mutyaba, Arthur; Kiggundu, Brian; Variava, Ebrahim; Ntsekhe, Mpiko
Despite evidence of myocardial infarct size reduction in animal studies, remote ischaemic conditioning (RIC) failed to improve clinical outcomes in the large CONDI-2/ERIC-PPCI trial. Potential reasons include that the predominantly low-risk study participants all received timely optimal reperfusion therapy by primary percutaneous coronary intervention (PPCI). Whether RIC can improve clinical outcomes in higher-risk STEMI patients in environments with poor access to early reperfusion or PPCI will be investigated in the RIC-AFRICA trial. The RIC-AFRICA study is a sub-Saharan African multi-centre, randomized, double-blind, sham-controlled clinical trial designed to test the impact of RIC on the composite endpoint of 30-day mortality and heart failure in 1200 adult STEMI patients without access to PPCI. Randomized participants will be stratified by whether or not they receive thrombolytic therapy within 12 h or arrive outside the thrombolytic window (12–24 h). Participants will receive either RIC (four 5-min cycles of inflation [20 mmHg above systolic blood pressure] and deflation of an automated blood pressure cuff placed on the upper arm) or sham control (similar protocol but with low-pressure inflation of 20 mmHg and deflation) within 1 h of thrombolysis and applied daily for the next 2 days. STEMI patients arriving greater than 24 h after chest pain but within 72 h will be recruited to participate in a concurrently running independent observational arm. The RIC-AFRICA trial will determine whether RIC can reduce rates of death and heart failure in higher-risk sub-optimally reperfused STEMI patients, thereby providing a low-cost, non-invasive therapy for improving health outcomes.
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Geothermal reservoir prediction using electrical resistivity maps: A case study of Lili Sepporaki Indonesia
(Journal of Applied and Physical Sciences, 2019-10-31) Mutebi, Denis; Haryanto, Agus Didit; Kazinda, Michael
The objective of this study is to predict the location of the geothermal reservoir through interpretation of Magnetotelluric depth-resistivity maps, with reference to Lili-Sepporaki geothermal area. Lili-Sepporaki is a nonmagmatic prospect located in Polewali Mandar, Western Sulawesi-Indonesia. The study area is dominated by andesitic to trachytic to trachytic tertiary volcanic products. The only thermal manifestations in the area are the hot springs and rock alterations. Previous geochemical studies found out the hot spring water has temperature of 98oC and the reservoir temperature of 190oC. A big portion of the surface rocks are weathered and hydrothermally altered owing to 􀅭indings from magnetic and Bouguer gravity surveys. This research utilized two-dimensional magnetotellurics data to locate resistivity anomalies in the subsurface. MT data was processed using SSMT2000 and MTEditor software programs while WinGLink software was used in the interpretation of the data. Four resistivity maps were obtained, each corresponding to one of the depths: 500 m; 1000 m; 1500 m; and 2000 m. There is a general sharp reduction in resistivity as opposed to the conventional resistivity of fresh igneous rocks. Analysis shows that the reservoir appears between depths of 1000 m and 2000 in different parts of the survey area, with prospect boundaries located in the South, South West and South East. A three-dimensional MT data analysis and exploration drilling are recommendable in order to get a detailed geothermal model.
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Opposition party institutionalisation in authoritarian settings: the case of Uganda
(Commonwealth & Comparative Politics, 2024-05-19) Bertrand, Eloïse; Mutyaba, Michael
This article analyses the process of institutionalisation among Ugandan opposition parties and highlights the tensions at play between party institutionalisation and broader party goals in authoritarian settings. Based upon qualitative research conducted between 2016 and 2023, we offer a historical analysis of the steps towards institutionalisation – understood as a process, rather than a state – taken by two Ugandan parties: the Forum for Democratic Change (FDC) and the Democratic Party (DP). Uganda features historical parties such as the DP that were severely weakened by the ‘Movement era’ but endured despite losing ground, and newer opposition forces, such as the FDC, that proved relatively stronger despite being divided over the question of building party structures, thus providing an interesting case study. Ultimately, this article demonstrates the complex, and at times conflicting, implications of institutionalisation for opposition parties’ ability to achieve their objectives in an authoritarian regime.
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Highly Heterogeneous Kaposi Sarcoma–Associated Herpesvirus Oral Shedding Kinetics Among People With and Without Kaposi Sarcoma and Human Immunodeficiency Virus Coinfection
(US: Oxford University Press., 2024-09-23) Krantz,Elizabeth M.; Mutyaba, Innocent; Nankoma, Janet; Orem, Jackson
An improved understanding of oral Kaposi sarcoma–associated herpesvirus (KSHV) viral dynamics could provide insights into transmission risk and guide vaccine development. We evaluated KSHV oral shedding dynamics in Ugandan adults stratified by Kaposi sarcoma (KS) and human immunodeficiency virus (HIV) status. Participants were followed for ≥4 weeks, with daily home oral swab collection to quantify KSHV using polymerase chain reaction. Shedding rates were defined by number of days with KSHV DNA detected divided by total days with swabs and compared by group using hurdle models. Two hundred ninety-five participants were enrolled; median age was 35 years (range, 18–71 years), and 134 (45%) were male. KSHV was detected more frequently among participants with KS (HIV positive [HIV+]/KS+, 56/76 [74%]; HIV negative [HIV−]/KS+, 9/18 [50%]) than those without KS (HIV+/KS−, 36/125 [29%]; HIV−/KS−, 16/76 [21%]); odds of shedding did not differ significantly by HIV status. Among participants with KSHV detected, shedding rates did not differ significantly by group. Median per-participant viral loads among positive samples were lowest in HIV+/KS+ (3.1 log10 copies/mL) and HIV−/KS+ (3.3 log10 copies/mL) participants relative to HIV+/KS− (3.8 log10 copies/mL) and HIV−/KS− (4.0 log10 copies/mL) participants. All groups had participants with low viral load intermittent shedding and participants with high viral load persistent shedding. Within each group, individual KSHV shedding rate positively correlated with median KSHV log10 copies/mL, and episode duration positively correlated with peak viral load. Oral KSHV shedding is highly heterogeneous across Ugandan adults with and without KS and HIV. Persistent shedding is associated with higher median viral loads regardless of HIV and KS status.