Efficacy of sulphadoxine–pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children

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dc.contributor.authorTalisun, Ambrose O.
dc.contributor.authorNalunkuma-Kazibwe, Anne
dc.contributor.authorBakyaita, Nathan
dc.contributor.authorLangi, Peter
dc.contributor.authorMutabingwa, Theonest K.
dc.contributor.authorWatkins, William W.
dc.contributor.authorMarck, Eric Van
dc.contributor.authorD’Alessandro, Umberto
dc.date.accessioned2022-05-28T17:40:49Z
dc.date.available2022-05-28T17:40:49Z
dc.date.issued2004
dc.description.abstractThe rapid development of falciparum resistance to sulphadoxine–pyrimethamine (SP) in East and Central Africa has raised concerns as to the efficacy of combining it with another drug. In 2002, we assessed the efficacy of SP alone and combined with amodiaquine (AQ/SP) or chloroquine (CQ/SP) in Ugandan children with uncomplicated falciparum malaria. At day 14, adequate clinical response was 100% (84/84) for AQ/SP, 93% (92/101) for CQ/SP and 91% (73/80) for SP. At day 28, parasitological failure (RI–RIII) occurred in 16% (13/80) of children treated with AQ/SP, in 48% (48/100) of those treated with CQ/SP and in 61% (48/79) of those treated with SP alone. Compared with the AQ/SP arm, the odds for parasitological failure at day 28 were five times higher (95% CI, 2–10) in the CQ/SP group and sevenfold higher (95% CI, 3–17) in that of SP alone. CQ/SP does not offer any significant added benefit over SP alone while AQ/SP is an efficacious low-cost combination. These findings have important policy implications for Uganda and other resource-constrained African countries faced with the problematic choice of a new first-line antimalarial treatment in a context of high CQ resistance.en_US
dc.identifier.citationTalisuna, A. O., Nalunkuma‐Kazibwe, A., Bakyaita, N., Langi, P., Mutabingwa, T. K., Watkins, W. W., ... & Egwang, T. G. (2004). Efficacy of sulphadoxine–pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children. Tropical medicine & international health, 9(2), 222-229.https://doi.org/10.1046/j.1365-3156.2003.01187.xen_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3614
dc.language.isoenen_US
dc.publisherTropical medicine & international healthen_US
dc.subjectin vivo efficacy, sulphadoxine–pyrimethamine, chloroquine, amodiaquine, combination therapy, falciparum malaria, Ugandaen_US
dc.titleEfficacy of sulphadoxine–pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan childrenen_US
dc.typeArticleen_US
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