The effects of male circumcision on female partners’ genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda

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dc.contributor.authorGray, Ronald H.
dc.contributor.authorKigozi, Godfrey
dc.contributor.authorSerwadda, David
dc.contributor.authorMakumbi, Fredrick
dc.contributor.authorNalugoda, Fred
dc.contributor.authorWatya, Stephen
dc.contributor.authorMoulton, Laurence
dc.contributor.authorCheng, Michael Z.
dc.contributor.authorSewankambo, Nelson K.
dc.contributor.authorKiwanuka, Noah
dc.contributor.authorSempijja, Victor
dc.contributor.authorLutalo, Tom
dc.contributor.authorKagayii, Joseph
dc.contributor.authorWabwire-Mangen, Fred
dc.contributor.authorRidzon, Renée
dc.contributor.authorBacon, Melanie
dc.contributor.authorWawer, Maria J.
dc.date.accessioned2022-03-11T06:54:52Z
dc.date.available2022-03-11T06:54:52Z
dc.date.issued2009
dc.description.abstractThe objective of the study was to assess effects of male circumcision on female genital symptoms and vaginal infections. STUDY DESIGN: Human immunodeficiency virus (HIV)-negative men enrolled in a trial were randomized to immediate or delayed circumcision (control arm). Genital symptoms, bacterial vaginosis (BV), and trichomonas were assessed in HIV-negative wives of married participants. Adjusted prevalence risk ratios (adjPRR) and 95% confidence intervals (CIs) were assessed by multivariable log-binomial regression, intent-to-treat analyses. RESULTS: A total of 783 wives of control and 825 wives of intervention arm men were comparable at enrollment. BV at enrollment was higher in control (38.3%) than intervention arm spouses (30.5%, P .001). At 1 year follow-up, intervention arm wives reported lower rates of genital ulceration (adjPRR, 0.78; 95% CI, 0.63-0.97), but there were no differences in vaginal discharge or dysuria. The risk of trichomonas was reduced in intervention arm wives (adjPRR, 0.52; 95% CI, 0.05- 0.98), as were the risks of any BV (adjPRR, 0.60; 95% CI, 0.38-0.94) and severe BV (prevalence risk ratios, 0.39; 95% CI, 0.24-0.64). CONCLUSION: Male circumcision reduces the risk of ulceration, trichomonas, and BV in female partners.en_US
dc.identifier.citationGray, R. H., Kigozi, G., Serwadda, D., Makumbi, F., Nalugoda, F., Watya, S., ... & Wawer, M. J. (2009). The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda. American journal of obstetrics and gynecology, 200(1), 42-e1.en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0002937808009010
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2676
dc.language.isoenen_US
dc.publisherAmerican journal of obstetrics and gynecologyen_US
dc.subjectbacterial vaginosisen_US
dc.subjectfemale genital ulcerationen_US
dc.subjectmale circumcisionen_US
dc.subjecttrichomonasen_US
dc.subjectvaginal infectionsen_US
dc.titleThe effects of male circumcision on female partners’ genital tract symptoms and vaginal infections in a randomized trial in Rakai, Ugandaen_US
dc.typeArticleen_US
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