Multidistrict Outbreak of Marburg Virus Disease—Uganda, 2012

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dc.contributor.authorKnust, Barbara
dc.contributor.authorSchafer, Ilana J.
dc.contributor.authorWamala, Joseph
dc.contributor.authorNyakarahuka, Luke
dc.contributor.authorOkot, Charles
dc.contributor.authorShoemaker, Trevor
dc.contributor.authorDodd, Kimberly
dc.contributor.authorGibbons, Aridth
dc.contributor.authorBalinandi, Stephen
dc.contributor.authorTumusiime, Alex
dc.contributor.authorCampbell, Shelley
dc.contributor.authorNewman, Edmund
dc.contributor.authorLasry, Estrella
dc.contributor.authorDeClerck, Hilde
dc.contributor.authorBoum, Yap
dc.contributor.authorMakumbi, Issa
dc.contributor.authorBosa, Henry Kyobe
dc.contributor.authorMbonye, Anthony
dc.contributor.authorAceng, Jane Ruth
dc.contributor.authorNichol, Stuart T.
dc.contributor.authorStröher, Ute
dc.contributor.authorRollin, Pierre E.
dc.date.accessioned2021-12-28T16:59:15Z
dc.date.available2021-12-28T16:59:15Z
dc.date.issued2015
dc.description.abstractIn October 2012, a cluster of illnesses and deaths was reported in Uganda and was confirmed to be an outbreak of Marburg virus disease (MVD). Patients meeting the case criteria were interviewed using a standard investigation form, and blood specimens were tested for evidence of acute or recent Marburg virus infection by reverse transcription–polymerase chain reaction (RT-PCR) and antibody enzyme-linked immunosorbent assay. The total count of confirmed and probable MVD cases was 26, of which 15 (58%) were fatal. Four of 15 laboratory-confirmed cases (27%) were fatal. Case patients were located in 4 different districts in Uganda, although all chains of transmission originated in Ibanda District, and the earliest case detected had an onset in July 2012. No zoonotic exposures were identified. Symptoms significantly associated with being a MVD case included hiccups, anorexia, fatigue, vomiting, sore throat, and difficulty swallowing. Contact with a case patient and attending a funeral were also significantly associated with being a case. Average RT-PCR cycle threshold values for fatal cases during the acute phase of illness were significantly lower than those for nonfatal cases. Following the institution of contact tracing, active case surveillance, care of patients with isolation precautions, community mobilization, and rapid diagnostic testing, the outbreak was successfully contained 14 days after its initial detection.en_US
dc.identifier.citationKnust, B., Schafer, I. J., Wamala, J., Nyakarahuka, L., Okot, C., Shoemaker, T., ... & Rollin, P. E. (2015). Multidistrict outbreak of Marburg virus disease—Uganda, 2012. The Journal of infectious diseases, 212(suppl_2), S119-S128. https://doi.org/10.1093/infdis/jiv351en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/946
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectMarburg virus, filoviruses, hemorrhagic fever, zoonotic disease, outbreak responseen_US
dc.titleMultidistrict Outbreak of Marburg Virus Disease—Uganda, 2012en_US
dc.typeArticleen_US
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