Prevalence and factors associated with non-adherence to multi-drug resistant tuberculosis (MDR-TB) treatment at Mulago National Referral Hospital, Kampala, Uganda

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dc.contributor.authorBatte, Charles
dc.contributor.authorNamusobya, Martha S.
dc.contributor.authorKirabo, Racheal
dc.contributor.authorMukisa, John
dc.contributor.authorAdakun, Susan
dc.contributor.authorKatamba, Achilles
dc.date.accessioned2023-01-18T19:20:59Z
dc.date.available2023-01-18T19:20:59Z
dc.date.issued2021
dc.description.abstractIn Uganda, 12% of previously treated TB cases and 1.6% of new cases have MDR-TB and require specialized treatment and care. Adherence is crucial for improving MDR-TB treatment outcomes. There is paucity of information on the extent to which these patients adhere to treatment and what the drivers of non-adherence are. Methods: We conducted a cohort study using retrospectively collected routine program data for patients treated for MDRTB between January 2012 – May 2016 at Mulago Hospital. We extracted anonymized data on non-adherence (missing 10% or more of DOT), socio-economic, demographic, and treatment characteristics of the patients. All participants were sensitive to MDR-TB drugs after second line Drug Susceptible Testing (DST) at entry into the study. Factors associated with non-adherence to MDR-TB treatment were determined using generalized linear models for the binomial family with log link and robust standard errors. We considered a p- value less than 0.05 as statistically significant. Results: The records of 227 MDR- TB patients met the inclusion criteria, 39.4% of whom were female, 32.6% aged between 25 – 34 years, and 54.6% living with HIV/AIDS. About 11.9% of the patients were non-adherent. The main driver for non-adherence was history of previous DR-TB treatment; previously treated DR-TB patients were 3.46 (Adjusted prevalence ratio: 3.46, 95 % CI: 1.68 - 7.14) times more likely to be non-adherent. Conclusion: One in 10 MDR-TB patients treated at Mulago hospital is non-adherent to treatment. History of previous DRTB treatment was significantly associated with non-adherence in this study. MDR-TB program should strengthen adherence counselling, strengthen DST surveillance, and close monitoring for previously treated DR-TB patients.en_US
dc.identifier.citationBatte C, Namusobya MS, Kirabo R, Mukisa J, Adakun S, Katamba A. Prevalence and factors associated with nonadherence to multi-drug resistant tuberculosis (MDR-TB) treatment at Mulago National Referral Hospital, Kampala, Uganda. Afri Health Sci. 2021;21(1):238-47. https://dx.doi.org/10.4314/ahs.v21i1.31en_US
dc.identifier.urihttps://dx.doi.org/10.4314/ahs.v21i1.31
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7064
dc.language.isoenen_US
dc.publisherAfrican Health Sciencesen_US
dc.subjectNon-adherenceen_US
dc.subjectMulti-drug resistant tuberculosisen_US
dc.subjectTreatmenten_US
dc.titlePrevalence and factors associated with non-adherence to multi-drug resistant tuberculosis (MDR-TB) treatment at Mulago National Referral Hospital, Kampala, Ugandaen_US
dc.typeArticleen_US
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