High rates of gastroesophageal cancers in patients with dyspepsia undergoing upper gastrointestinal endoscopy in Uganda
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Endoscopy International Open
Abstract
Background and study aims Dyspepsia is the most common
presenting symptom in the gastrointestinal clinic of
Mulago National Referral hospital. The etiology is essentially
not fully described in our patient population. This study
was therefore conducted to establish the causes of dyspepsia
based on endoscopic diagnosis among patients with
dyspepsia seeking care at the National Referral hospital of
Uganda.
Patients and methods This retrospective study conducted
in the endoscopy unit of Mulago hospital reviewed 356
patient endoscopy reports spanning January 2018 to July
2020 with a focus on those with a referral indication of dyspepsia.
Age and sex were the independent variables of interest
while the endoscopy findings as reported by the
endoscopist were the outcome variable of interest.
Results Of the 356 endoscopy reports reviewed, 159 met
the inclusion criterion of dyspepsia as the indication. Participant
mean age was 47.7 years (± 16.53) with the majority
(25.79 %) in the fifth decade while the male to female ratio
was 1. The majority of patients had organic dyspepsia
(90.57 %) while the commonest finding was gastritis 69
(43.4%). Gastroesophageal cancers represented (18)
11.32% of all findings. There was a positive association between
age > 50 years with gastroesophageal cancers
(7.639) as well as age < 50 years and functional dyspepsia
(2.794); however, all these were not statistically significant
(P = 0.006 and (P = 0.095, respectively).
Conclusions Organic/structural dyspepsia comprises over
90% of investigated dyspepsia with 11% comprising cancer
among patients seeking endoscopy at the National Referral
Hospital of Uganda.
Description
Keywords
Gastroesophageal cancers, Patients, Dyspepsia, Gastrointestinal endoscopy
Citation
Mbiine, R., Nakanwagi, C., & Kituuka, O. (2021). High rates of gastroesophageal cancers in patients with dyspepsia undergoing upper gastrointestinal endoscopy in Uganda. Endoscopy International Open, 9(07), E997-E1000. 10.1055/a-1480-7231