Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infection

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dc.contributor.authorLeidl, L.
dc.contributor.authorMayanja-Kizza, H.
dc.contributor.authorSotgiu, G.
dc.contributor.authorBaseke, J.
dc.contributor.authorErnst, M.
dc.contributor.authorHirsch, C.
dc.contributor.authorGolettie, D.
dc.contributor.authorToossi, Z.
dc.contributor.authorLange, C.
dc.date.accessioned2022-05-20T05:09:22Z
dc.date.available2022-05-20T05:09:22Z
dc.date.issued2010
dc.description.abstractInfection with HIV is the greatest risk factor for tuberculosis (TB) in Africa. Tuberculin skin test (TST), QuantiFERON-TB Gold In-Tube (QFT-G-IT) and T-Spot.TB assays were performed in newly diagnosed HIV-infected individuals with and without active TB and in HIV-uninfected subjects at a university outpatient clinic in Kampala, Uganda. A total of 135 individuals were enrolled: 109 with a new diagnosis of HIV-1 infection but no active TB, 19 with HIV-1 infection and active TB, and seven HIV-uninfected healthy subjects. In control subjects immune responses were positive in 57.2% by TST and in 100% by at least one interferon-γ release assay.In HIV-1 infected patients without active TB, induration in the TST (mm) (rho = 0.41, p-value <0.0001) and concentration of interferon (IFN)-γ in the QFT-G-IT tube with Mycobacterium tuberculosis-specific antigens (rho = 0.38; p = 0.0001) were negatively correlated to numbers of circulating CD4+ T-cells, while numbers of IFN-γ producing cells (rho = 0.03–0.13; p-value = 0.21–0.77) and frequencies of positive test results for the T-Spot.TB test among groups of patients with different levels of immunodeficiency remained constant (p-value = 0.46).In HIV-1 infection, TST and QFT-G-IT immune responses are both strongly related to the degree of immunodeficiency, while results of the T-Spot.TB are independent of the level of CD4+ T-cell depletion.en_US
dc.identifier.citationLeidl, L., Mayanja-Kizza, H., Sotgiu, G., Baseke, J., Ernst, M., Hirsch, C., ... & Lange, C. (2010). Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infection. European Respiratory Journal, 35(3), 619-626.DOI: 10.1183/09031936.00045509en_US
dc.identifier.issn1399-3003
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3271
dc.language.isoenen_US
dc.publisherEuropean Respiratory Journalen_US
dc.subjectCulture filtrate protein-10, early secretory antigenic target-6, HIV, interferon-c release assay, latent tuberculosis infection, tuberculosisen_US
dc.titleRelationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infectionen_US
dc.typeArticleen_US
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