Severe COVID-19 in Uganda across Two Epidemic Phases: A Prospective Cohort Study

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dc.contributor.authorBakamutumaho, Barnabas
dc.contributor.authorMatthew, J. Cummings
dc.contributor.authorOwor, Nicholas
dc.contributor.authorKayiwa, John
dc.contributor.authorNamulondo, Joyce
dc.contributor.authorByaruhanga, Timothy
dc.contributor.authorMuwanga, Moses
dc.contributor.authorNsereko, Christopher
dc.contributor.authorRwamutwe, Emmanuel
dc.contributor.authorMutonyi, Roselyn
dc.contributor.authorAchan, Josephine
dc.contributor.authorWanyenze, Lucy
dc.contributor.authorNdazarwe, Alice
dc.contributor.authorNakanjako, Ruth
dc.contributor.authorNatuhwera, Richard
dc.contributor.authorNsangi, Annet
dc.contributor.authorBosa, Henry Kyobe
dc.contributor.authorOcom, Felix
dc.contributor.authorMax, R. O’Donnell
dc.contributor.authorKikaire, Bernard
dc.contributor.authorLutwama, Julius J.
dc.date.accessioned2025-03-09T11:01:23Z
dc.date.available2025-03-09T11:01:23Z
dc.date.issued2021
dc.description.abstractAmong a prospective cohort of children and adults admitted to a national COVID-19 treatment unit in Uganda from March to December 2020, we characterized the epidemiology of and risk factors for severe illness. Across two epidemic phases differentiated by varying levels of community transmission, the proportion of patients admitted with WHO-defined severe COVID-19 ranged from 5% (7/146; 95% CI: 2–10) to 33% (41/124; 95% CI: 25–42); 21% (26/124; 95% CI: 14–29%) of patients admitted during the peak phase received oxygen therapy. Severe COVID-19 was associated with older age, male sex, and longer duration of illness before admission. Coinfection with HIV was not associated with illness severity; malaria or tuberculosis coinfection was rare. No patients died during admission. Despite low mortality, hospital incidence of severe COVID-19 during the first epidemic peak in Uganda was substantial. Improvements in vaccine deployment and acute care capacity, including oxygen delivery, are urgently needed to prevent and manage severe COVID-19 in sub-Saharan Africa.
dc.identifier.citationBakamutumaho, B., Cummings, M. J., Owor, N., Kayiwa, J., Namulondo, J., Byaruhanga, T., ... & of COVID, L. C. (2021). Severe COVID-19 in Uganda across two epidemic phases: a prospective cohort study. The American journal of tropical medicine and hygiene, 105(3), 740. doi:10.4269/ajtmh.21-0551
dc.identifier.other10.4269/ajtmh.21-0551
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10079
dc.language.isoen
dc.publisherThe American journal of tropical medicine and hygiene
dc.titleSevere COVID-19 in Uganda across Two Epidemic Phases: A Prospective Cohort Study
dc.typeArticle
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