Infectiousness of HIV-Seropositive Patients with Tuberculosis in a High-Burden African Setting

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dc.contributor.authorMartinez, Leonardo
dc.contributor.authorSekandi, Juliet N.
dc.contributor.authorCastellanos, Maria E.
dc.contributor.authorZalwango, Sarah
dc.contributor.authorWhalen, Christopher C.
dc.date.accessioned2021-12-10T11:35:47Z
dc.date.available2021-12-10T11:35:47Z
dc.date.issued2016
dc.description.abstractPolicy recommendations on contact investigation of HIV-seropositive patients with tuberculosis have changed several times. Current epidemiologic evidence informing these recommendations is considered low quality, and few large studies investigating the infectiousness of HIV-seropositive and -seronegative index cases have been performed in sub-Saharan Africa. Objectives: We assessed the infectiousness of HIV-seropositive and -seronegative patients with tuberculosis to their household contacts and examined potential modifiers of this relationship. Methods: Adults suffering from their first episode of pulmonary tuberculosis were identified in Kampala, Uganda. Field workers visited index households and enrolled consenting household contacts. Latent tuberculosis infection was measured through tuberculin skin testing, and relative risks were calculated using modified Poisson regression models. Standard assessments of interaction between latent tuberculosis infection, the HIV serostatus of index cases, and other variables were performed.en_US
dc.identifier.citationStein, CM, Zalwango, S., Malone, LL, Won, S., Mayanja-Kizza, H., Mugerwa, RD, ... & Whalen, CC (2008). Genome scan of M. tuberculosis infection and disease in Ugandans. PloS one , 3 (12), e4094. DOI: 10.1164/rccm.201511-2146OCen_US
dc.identifier.other10.1164/rccm.201511-2146OC
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/247
dc.language.isoenen_US
dc.publisherPloS oneen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectHousehold contactsen_US
dc.subjectHIVen_US
dc.subjectTuberculosis infectionen_US
dc.subjectInfectiousnessen_US
dc.titleInfectiousness of HIV-Seropositive Patients with Tuberculosis in a High-Burden African Settingen_US
dc.typeArticleen_US
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