Hepatitis C in Uganda: Identification of infected blood donors for micro-elimination

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dc.contributor.authorNankya-Mutyoba, Joan
dc.contributor.authorApica, Betty S.
dc.contributor.authorOtekat, Grace
dc.contributor.authorKyeyune, Dorothy B.
dc.contributor.authorNakyagaba, Lourita
dc.contributor.authorNabunje, Joletta
dc.contributor.authorNakafeero, Mary
dc.contributor.authorSeremba, Emmanuel
dc.contributor.authorOcama, Ponsiano
dc.date.accessioned2022-07-28T12:52:15Z
dc.date.available2022-07-28T12:52:15Z
dc.date.issued2021
dc.description.abstractThe drive to eliminate viral hepatitis by 2030 is underway. However, locally generated data on active infection is required to focus such efforts. We performed a regionally-inclusive survey to determine prevalence of active HCV, genotypes and related factors among Ugandan blood donors. Methods: Participants from regional blood banks and blood collection centers were surveyed for information on demographic, clinical and lifestyle factors. Blood was assayed for HCV infection, HCV genotypes and subtypes. Logistic regression was performed to determine factors associated with active HCV infection. Results: Of 1243 participants, 1041 (83.7%) were male, average age (SD), 27.7 (9.8). Prevalence of active HCV infection was 7.8% and we identified 3 genotypes. Median age (adj. OR (95% CI) = 1.03 (1.01–1.06), p-value = 0.040)), Northern region of birth versus Central or Eastern (adj. OR (95% CI) = 10.25 (2.65–39.68), p-value = 0.001)), Northern residence, versus Central or Eastern (adj. OR (95% CI) = 0.23 (0.08–0.65), p-value = 0.006)), and being married (versus single/divorced) adj. OR 2.49(1.3–4.79), p-value = 0.006 were associated with active HCV infection. Conclusion: Targeted interventions in at-risk populations coupled with linkage to care and treatment will help achieve the WHO elimination goals in this setting.en_US
dc.identifier.citationNankya-Mutyoba, J., Apica, B. S., Otekat, G., Kyeyune, D. B., Nakyagaba, L., Nabunje, J., ... & Ocama, P. (2021). Hepatitis C in Uganda: Identification of infected blood donors for micro-elimination. Journal of Virus Eradication, 7(2), 100041. https://doi.org/10.1016/j.jve.2021.100041en_US
dc.identifier.urihttps://doi.org/10.1016/j.jve.2021.100041
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4234
dc.language.isoenen_US
dc.publisherJournal of Virus Eradicationen_US
dc.subjectHepatitis Cen_US
dc.subjectBlood donorsen_US
dc.subjectUgandaen_US
dc.titleHepatitis C in Uganda: Identification of infected blood donors for micro-eliminationen_US
dc.typeArticleen_US
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