Cassava brown streak virus has a rapidly evolving genome: implications for virus speciation, variability, diagnosis and host resistance

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dc.contributor.authorAlicai, Titus
dc.contributor.authorNdunguru, Joseph
dc.contributor.authorSseruwagi, Peter
dc.contributor.authorTairo, Fred
dc.contributor.authorOkao-Okuja, Geoffrey
dc.contributor.authorNanvubya, Resty
dc.contributor.authorKiiza, Lilliane
dc.contributor.authorKubatko, Laura
dc.contributor.authorKehoe, Monica A.
dc.contributor.authorBoykin, Laura M.
dc.date.accessioned2022-06-23T17:36:43Z
dc.date.available2022-06-23T17:36:43Z
dc.date.issued2016
dc.description.abstractCassava is a major staple food for about 800 million people in the tropics and sub-tropical regions of the world. Production of cassava is significantly hampered by cassava brown streak disease (CBSD), caused by Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). The disease is suppressing cassava yields in eastern Africa at an alarming rate. Previous studies have documented that CBSV is more devastating than UCBSV because it more readily infects both susceptible and tolerant cassava cultivars, resulting in greater yield losses. Using whole genome sequences from NGS data, we produced the first coalescent-based species tree estimate for CBSV and UCBSV. This species framework led to the finding that CBSV has a faster rate of evolution when compared with UCBSV. Furthermore, we have discovered that in CBSV, nonsynonymous substitutions are more predominant than synonymous substitution and occur across the entire genome. All comparative analyses between CBSV and UCBSV presented here suggest that CBSV may be outsmarting the cassava immune system, thus making it more devastating and harder to control.en_US
dc.identifier.citationAlicai, T., Ndunguru, J., Sseruwagi, P., Tairo, F., Okao-Okuja, G., Nanvubya, R., ... & Boykin, L. M. (2016). Cassava brown streak virus has a rapidly evolving genome: implications for virus speciation, variability, diagnosis and host resistance. Scientific reports, 6(1), 1-14. DOI: 10.1038/srep36164en_US
dc.identifier.other10.1038/srep36164
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4059
dc.language.isoenen_US
dc.publisherScientific reportsen_US
dc.subjectCassava brown streak virusen_US
dc.subjectGenomeen_US
dc.subjectVirus speciationen_US
dc.subjectResistanceen_US
dc.titleCassava brown streak virus has a rapidly evolving genome: implications for virus speciation, variability, diagnosis and host resistanceen_US
dc.typeArticleen_US
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