Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals

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dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorKhoo, Saye
dc.contributor.authorMerry, Concepta
dc.contributor.authorVan geertruyden, Jean-Pierre Van geertruyden4
dc.date.accessioned2022-01-12T08:26:41Z
dc.date.available2022-01-12T08:26:41Z
dc.date.issued2011
dc.description.abstractTreatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemetherlumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria. The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. Both artemether and lumefantrine aremetabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used forHIV treatment. Coadministration of NNRTIs and PIs with AL could potentially cause complex pharmacokinetic drug interactions. NNRTI by inducing CYP450 3A4 enzyme and PIs by inhibiting CYP450 3A4 enzymes could influence both artemether and lumefantrine concentrations and their active metabolites dihydroartemisinin and desbutyl-lumefantrine, predisposing patients to poor treatment response, toxicity, and risk for development of resistance. There are scanty data on these interactions and their consequences. Pharmacokinetic studies to evaluate these interactions in the target populations are urgently needed.en_US
dc.identifier.citationByakika-Kibwika, P., Lamorde, M., Mayanja-Kizza, H., Khoo, S., & Merry, C. (2011). Artemether-lumefantrine combination therapy for treatment of uncomplicated malaria: the potential for complex interactions with antiretroviral drugs in HIV-infected individuals. Malaria research and treatment , doi:10.4061/2011/703730en_US
dc.identifier.other10.4061/2011/703730
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1203
dc.language.isoenen_US
dc.publisherMalaria Research and Treatmenten_US
dc.subjectArtemether-Lumefantrine Combination Therapyen_US
dc.subjectTreatment of Uncomplicated Malariaen_US
dc.subjectAntiretroviral Drugsen_US
dc.subjectHIV-Infected Individualsen_US
dc.titleArtemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individualsen_US
dc.typeArticleen_US
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