Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda

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dc.contributor.authorMa, Ningning
dc.contributor.authorZalwango, Sarah
dc.contributor.authorMalone, LaShaunda L
dc.contributor.authorNsereko, Mary
dc.contributor.authorWampande, Eddie M
dc.contributor.authorThiel, Bonnie A
dc.contributor.authorOkware, Brenda
dc.contributor.authorIgo Jr., Robert P
dc.contributor.authorJoloba3, Moses L.
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorBoom, Henry
dc.contributor.authorStein, Catherine M
dc.date.accessioned2021-12-09T11:19:44Z
dc.date.available2021-12-09T11:19:44Z
dc.date.issued2014
dc.description.abstractBackground: Despite sustained exposure to a person with pulmonary tuberculosis (TB), some M. tuberculosis (Mtb) exposed individuals maintain a negative tuberculin skin test (TST). Our objective was to characterize these persistently negative TST (PTST-) individuals and compare them to TST converters (TSTC) and individuals who are TST positive at study enrollment. Methods: During a TB household contact study in Kampala, Uganda, PTST-, TSTC, and TST + individuals were identified. PTST- individuals maintained a negative TST over a 2 year observation period despite prolonged exposure to an infectious tuberculosis (TB) case. Epidemiological and clinical characteristics were compared, a risk score developed by another group to capture risk for Mtb infection was computed, and an ordinal regression was performed. Results: When analyzed independently, epidemiological risk factors increased in prevalence from PTST- to TSTC to TST+. An ordinal regression model suggested age (p < 0.01), number of windows (p < 0.01) and people (p = 0.07) in the home, and sleeping in the same room (p < 0.01) were associated with PTST- and TSTC. As these factors do not exist in isolation, we examined a risk score, which reflects an accumulation of risk factors. This compound exposure score did not differ significantly between PTST-, TSTC, and TST+, except for the 5–15 age group (p = 0.009). Conclusions: Though many individual factors differed across all three groups, an exposure risk score reflecting a collection of risk factors did not differ for PTST-, TSTC and TST + young children and adults. This is the first study to rigorously characterize the epidemiologic risk profile of individuals with persistently negative TSTs despite close exposure to a person with TB. Additional studies are needed to characterize possible epidemiologic and host factors associated with this phenotype.en_US
dc.identifier.citationMa et al.: Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda. BMC Infectious Diseases 2014 14:352. doi:10.1186/1471-2334-14-352en_US
dc.identifier.other10.1186/1471-2334-14-352
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/221
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subjectTransmission risk factorsen_US
dc.subjectLatent Mtb infectionen_US
dc.subjectExposure,en_US
dc.subjectHousehold characteristicsen_US
dc.subjectPPD testen_US
dc.titleClinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Ugandaen_US
dc.typeArticleen_US
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