Diabetes and Pre-Diabetes among Persons Aged 35 to 60 Years in Eastern Uganda: Prevalence and Associated Factors

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dc.contributor.authorMayega, Roy William
dc.contributor.authorGuwatudde, David
dc.contributor.authorMakumbi, Fredrick
dc.contributor.authorNakwagala, Frederick Nelson
dc.contributor.authorPeterson, Stefan
dc.contributor.authorTomson, Goran
dc.contributor.authorOstenson, Claes-Goran
dc.date.accessioned2022-02-05T12:54:41Z
dc.date.available2022-02-05T12:54:41Z
dc.date.issued2013
dc.description.abstractOur aim was to estimate the prevalence of abnormal glucose regulation (AGR) (i.e. diabetes and prediabetes) and its associated factors among people aged 35-60 years so as to clarify the relevance of targeted screening in rural Africa. Methods: A population-based survey of 1,497 people (786 women and 711 men) aged 35-60 years was conducted in a predominantly rural Demographic Surveillance Site in eastern Uganda. Participants responded to a lifestyle questionnaire, following which their Body Mass Index (BMI) and Blood Pressure (BP) were measured. Fasting plasma glucose (FPG) was measured from capillary blood using On-Call® Plus (Acon) rapid glucose meters, following overnight fasting. AGR was defined as FPG ≥6.1mmol L-1 (World Health Organization (WHO) criteria or ≥5.6mmol L-1 (American Diabetes Association (ADA) criteria. Diabetes was defined as FPG >6.9mmol L-1, or being on diabetes treatment. Results: The mean age of participants was 45 years for men and 44 for women. Prevalence of diabetes was 7.4% (95%CI 6.1-8.8), while prevalence of pre-diabetes was 8.6% (95%CI 7.3-10.2) using WHO criteria and 20.2% (95%CI 17.5-22.9) with ADA criteria. Using WHO cut-offs, the prevalence of AGR was 2 times higher among obese persons compared with normal BMI persons (Adjusted Prevalence Rate Ratio (APRR) 1.9, 95%CI 1.3-2.8). Occupation as a mechanic, achieving the WHO recommended physical activity threshold, and higher dietary diversity were associated with lower likelihood of AGR (APRR 0.6, 95%CI 0.4-0.9; APRR 0.6, 95%CI 0.4-0.8; APRR 0.5, 95%CI 0.3-0.9 respectively). The direct medical cost of detecting one person with AGR was two US dollars with ADA and three point seven dollars with WHO cut-offs. Conclusions: There is a high prevalence of AGR among people aged 35-60 years in this setting. Screening for high risk persons and targeted health education to address obesity, insufficient physical activity and non-diverse diets are necessary.en_US
dc.identifier.citation: Mayega RW, Guwatudde D, Makumbi F, Nakwagala FN, Peterson S, et al. (2013) Diabetes and Pre-Diabetes among Persons Aged 35 to 60 Years in Eastern Uganda: Prevalence and Associated Factors. PLoS ONE 8(8): e72554. doi:10.1371/journal.pone.0072554en_US
dc.identifier.other10.1371/journal.pone.0072554
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1948
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectDiabetesen_US
dc.subjectPre-Diabetesen_US
dc.subjectYearsen_US
dc.subjectEastern Ugandaen_US
dc.subjectPrevalenceen_US
dc.titleDiabetes and Pre-Diabetes among Persons Aged 35 to 60 Years in Eastern Uganda: Prevalence and Associated Factorsen_US
dc.typeArticleen_US
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