Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial

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dc.contributor.authorGuédou, Fernand A.
dc.contributor.authorDamme, Lut Van
dc.contributor.authorDeese, Jennifer
dc.contributor.authorCrucitti, Tania
dc.contributor.authorBecker, Marissa
dc.contributor.authorMirembe, Florence
dc.contributor.authorSolomon, Suniti
dc.contributor.authorAlary, Michel
dc.date.accessioned2022-01-21T05:56:54Z
dc.date.available2022-01-21T05:56:54Z
dc.date.issued2013
dc.description.abstractData on risk factors of recurrent bacterial vaginosis (RBV) are still scarce. We used data from female sex workers (FSW) participating in a randomized controlled microbicide trial to examine predictors of BV recurrence. Methods: Trial’s participants with at least an episode of BV which was treated and/or followed by a negative BV result and at least one subsequent visit offering BV testing were included in the analysis. Behavioural and medical data were collected monthly while laboratory testing for STI and genital tract infections were performed quarterly. The Andersen-Gill proportional hazards model was used to determine predictors of BV recurrence both in bivariate and multivariate analyses. Results: 440 women were included and the incidence rate for RBV was 20.8 recurrences/100 person-months (95% confidence interval (CI) =18.1–23.4). In the multivariate analysis controlling for the study site, recent vaginal cleansing as reported at baseline with adjusted hazard-ratio (aHR)=1.30, 95% CI = 1.02-1.64 increased the risk of BV recurrence, whereas consistent condom use (CCU) with the primary partner (aHR=0.68, 95% CI=0.49-0.93) and vaginal candidiasis (aHR=0.70, 95% CI=0.53-0.93), both treated as time-dependent variables, were associated with decreased risk of RBV. Conclusion: This study confirms the importance of counselling high-risk women with RBV about the adverse effects of vaginal cleansing and the protective effects of condom use with all types of partners for the prevention of sexually transmitted infections, including BV. More prospective studies on risk factors of BV recurrence are warranted.en_US
dc.identifier.citationGuédou et al.: Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial. BMC Infectious Diseases 2013 13:208. doi:10.1186/1471-2334-13-208en_US
dc.identifier.other10.1186/1471-2334-13-208
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1380
dc.language.isoenen_US
dc.publisherBMC Infectious Diseasesen_US
dc.subjectBacterial vaginosisen_US
dc.subjectRecurrenceen_US
dc.subjectPredictorsen_US
dc.subjectFemale sex workersen_US
dc.subjectMicrobicide trialen_US
dc.titleBehavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trialen_US
dc.typeArticleen_US
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