The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project

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dc.contributor.authorKirenga, Bruce J
dc.contributor.authorChakaya, Jeremiah
dc.contributor.authorYimer, Getnet
dc.contributor.authorNyale, George
dc.contributor.authorHaile, Tewodros
dc.contributor.authorMuttamba, Winters
dc.contributor.authorMugenyi, Levicatus
dc.contributor.authorKatagira, Winceslaus
dc.contributor.authorWorodria, William
dc.contributor.authorAanyu-Tukamuhebwa, Hellen
dc.contributor.authorLugogo, Njira
dc.contributor.authorJoloba, Moses
dc.contributor.authorMersha, Tesfaye B.
dc.contributor.authorBekele, Amsalu
dc.contributor.authorMakumbi, Fred
dc.contributor.authorMekasha, Amha
dc.contributor.authorGreen, Cynthia L.
dc.contributor.authorde Jong, Corina
dc.contributor.authorKamya, Moses
dc.contributor.authorvan der Molen, Thys
dc.date.accessioned2024-05-03T12:37:49Z
dc.date.available2024-05-03T12:37:49Z
dc.date.issued2024-01-09
dc.description.abstractBackground: Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. Objective: We sought to determine the burden (prevalence, mortality, and activity and work impairment) of severe asthma in 3 countries in East Africa: Uganda, Kenya, and Ethiopia. Methods: Using the American Thoracic Society/European Respiratory Society case definition of severe asthma, we analyzed for the prevalence of severe asthma (requiring Global Initiative for Asthma [GINA] steps 4-5 asthma medications for the previous year to achieve control) and severe refractory asthma (remains uncontrolled despite treatment with GINA steps 4-5 asthma medications) in a cohort of 1086 asthma patients who had been in care for 12 months and had received all GINA-recommended medications. Asthma control was assessed by the asthma control questionnaire (ACQ). Results: Overall, the prevalence of severe asthma and severe refractory asthma was 25.6% (95% confidence interval [CI], 23.1-28.3) and 4.6% (95% CI, 3.5-6.0), respectively. Patients with severe asthma were (nonsevere vs severe vs severe refractory) older (39, 42, 45 years, P = .011), had high skin prick test reactivity (67.1%, 76.0%, 76.0%, P = .004), had lower forced expiratory volume in 1 second percentage (81%, 61%, 55.5%, P < .001), had lower quality of life score (129, 127 vs 121, P < .001), and had higher activity impairment (10%, 30%, 50%, P < .001). Factors independently associated with severe asthma were hypertension comorbidity; adjusted odds ratio 2.21 (1.10-4.47), P = .027, high bronchial hyperresponsiveness questionnaire score; adjusted odds ratio 2.16 (1.01-4.61), P = .047 and higher ACQ score at baseline 2.80 (1.55-5.08), P = .001. Conclusion: The prevalence of severe asthma in Africa is high and is associated with high morbidity and poor quality of life.en_US
dc.identifier.citationKirenga, Bruce J., Jeremiah Chakaya, Getnet Yimer, et al. 'The Burden of Severe Asthma in Sub-Saharan Africa: Findings from the African Severe Asthma Project', The Journal of Allergy and Clinical Immunology. Global, vol. 3/no. 2, (2024), pp. 100209-100209.en_US
dc.identifier.issnISSN 2772-8293
dc.identifier.issnEISSN 2772-8293
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9502
dc.language.isoenen_US
dc.publisherElsevier Incen_US
dc.subjectSevere asthma burden of severe asthma severe asthma determinants sub-Saharan Africaen_US
dc.titleThe burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Projecten_US
dc.typeArticleen_US
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