Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

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dc.contributor.authorTusiime, Jayne Byakika
dc.contributor.authorCrane, Johanna
dc.contributor.authorOyugi, Jessica H.
dc.contributor.authorRagland, Kathleen
dc.contributor.authorKawuma, Annet
dc.contributor.authorMusoke, Philippa
dc.contributor.authorBangsberg, David R.
dc.date.accessioned2022-01-29T13:31:15Z
dc.date.available2022-01-29T13:31:15Z
dc.date.issued2009
dc.description.abstractWe conducted a study to assess the effect of family-based treatment on adherence amongst HIV-infected parents and their HIV-infected children attending the Mother-To-Child-Transmission Plus program in Kampala, Uganda. Adherence was assessed using home-based pill counts and self-report. Mean adherence was over 94%. Depression was associated with incomplete adherence on multivariable analysis. Adherence declined over time. Qualitative interviews revealed lack of transportation money, stigma, clinical response to therapy, drug packaging, and cost of therapy may impact adherence. Our results indicate that providing ART to all eligible HIV-infected members in a household is associated with excellent adherence in both parents and children. Adherence to ART among new parents declines over time, even when patients receive treatment at no cost. Depression should be addressed as a potential barrier to adherence. Further study is necessary to assess the long-term impact of this family treatment model on adherence to ART in resource-limited settings.en_US
dc.identifier.citationByakika-Tusiime, J., Crane, J., Oyugi, J. H., Ragland, K., Kawuma, A., Musoke, P., & Bangsberg, D. R. (2009). Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-Plus family treatment model: role of depression in declining adherence over time. AIDS and Behavior, 13(1), 82-91.https://doi.org/10.1007/s10461-009-9546-xen_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1615
dc.language.isoenen_US
dc.publisherAIDS and Behavioren_US
dc.subjectUganda; Adherence; Antiretroviral therapy; Household; MTCT-Plusen_US
dc.titleLongitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Timeen_US
dc.typeArticleen_US
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