Accuracy and Incremental Yield of the Chest X-Ray in Screening for Tuberculosis in Uganda: A Cross-Sectional Study

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dc.contributor.authorNalunjogi, Joanitah
dc.contributor.authorMugabe, Frank
dc.contributor.authorNajjingo, Irene
dc.contributor.authorLusiba, Pastan
dc.contributor.authorOlweny, Francis
dc.contributor.authorMubiru, Joseph
dc.contributor.authorKayongo, Edward
dc.contributor.authorSekibira, Rogers
dc.contributor.authorKatamba, Achilles
dc.contributor.authorKirenga, Bruce
dc.date.accessioned2023-01-15T12:40:24Z
dc.date.available2023-01-15T12:40:24Z
dc.date.issued2021
dc.description.abstractTheWHOEND TB strategy requires ≥90% case detection to combat tuberculosis (TB). Increased TB case detection requires a more sensitive and specific screening tool. Currently, the symptoms recommended for screening TB have been found to be suboptimal since up to 44% of individuals with TB are asymptomatic. The chest X-ray (CXR) as a screening tool for pulmonary TB was evaluated in this study, as well as its incremental yield in TB diagnosis using a cross-sectional study involving secondary analysis of data of 4512 consented/assented participants ≥15 years who participated in the Uganda National TB prevalence survey between 2014 and 2015. Participants with a cough ≥2 weeks, fever, weight loss, and night sweats screened positive for TB using the symptoms screening method, while participants with a TB defining abnormality on CXR screened positive for TB by the CXR screening method. The Löwenstein-Jensen (LJ) culture was used as a gold standard for TB diagnosis. The CXR had 93% sensitivity and 65% specificity compared to LJ culture results, while symptoms had 76% sensitivity and 31% specificity. The screening algorithm involving the CXR in addition to symptoms led to a 38% increment in the yield of diagnosed tuberculosis. The number needed to screen using the CXR and symptoms screening algorithm was 32 compared to 45 when the symptoms are used alone. Therefore, the CXR in combination with symptoms is a good TB screening tool and increases the yield of diagnosed TB.en_US
dc.identifier.citationNalunjogi, J., Mugabe, F., Najjingo, I., Lusiba, P., Olweny, F., Mubiru, J., ... & Kirenga, B. (2021). Accuracy and incremental yield of the chest X-ray in screening for tuberculosis in Uganda: a cross-sectional study. Tuberculosis research and treatment, 2021. https://doi.org/10.1155/2021/6622809en_US
dc.identifier.urihttps://doi.org/10.1155/2021/6622809
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6951
dc.language.isoenen_US
dc.publisherTuberculosis research and treatmenten_US
dc.subjectAccuracyen_US
dc.subjectIncremental Yielden_US
dc.subjectChest X-Rayen_US
dc.subjectTuberculosisen_US
dc.titleAccuracy and Incremental Yield of the Chest X-Ray in Screening for Tuberculosis in Uganda: A Cross-Sectional Studyen_US
dc.typeArticleen_US
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