Combining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Fever

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dc.contributor.authorVajana, Elia
dc.contributor.authorBarbato, Mario
dc.contributor.authorColli, Licia
dc.contributor.authorMilanesi, Marco
dc.contributor.authorRochat, Estelle
dc.contributor.authorFabrizi, Enrico
dc.contributor.authorMukasa, Christopher
dc.contributor.authorDel Corvo, Marcello
dc.contributor.authorMasembe, Charles
dc.contributor.authorMuwanika, Vincent B.
dc.contributor.authorKabi, Fredrick
dc.contributor.authorStewart Sonstegard, Tad
dc.contributor.authorHuson, Heather Jay
dc.contributor.authorNegrini, Riccardo
dc.contributor.authorConsortium, NextGen
dc.contributor.authorJoost, Stéphane
dc.contributor.authorAjmone-Marsan, Paolo
dc.date.accessioned2023-05-04T15:05:51Z
dc.date.available2023-05-04T15:05:51Z
dc.date.issued2018
dc.description.abstractEast Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and caused by the protozoan Theileria parva parva, which invades host lymphocytes and promotes their clonal expansion. Importantly, indigenous cattle show tolerance to infection in ECF-endemically stable areas. Here, the putative genetic bases underlying ECF-tolerance were investigated using molecular data and epidemiological information from 823 indigenous cattle from Uganda. Vector distribution and host infection risk were estimated over the study area and subsequently tested as triggers of local adaptation by means of landscape genomics analysis. We identified 41 and seven candidate adaptive loci for tick resistance and infection tolerance, respectively. Among the genes associated with the candidate adaptive loci are PRKG1 and SLA2. PRKG1 was already described as associated with tick resistance in indigenous South African cattle, due to its role into inflammatory response. SLA2 is part of the regulatory pathways involved into lymphocytes’ proliferation. Additionally, local ancestry analysis suggested the zebuine origin of the genomic region candidate for tick resistance.en_US
dc.identifier.citationVajana E, Barbato M, Colli L, Milanesi M, Rochat E, Fabrizi E, Mukasa C, Del Corvo M, Masembe C, Muwanika VB, Kabi F, Sonstegard TS, Huson HJ, Negrini R, The NextGen Consortium, Joost S and Ajmone-Marsan P (2018) Combining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Fever. Front. Genet. 9:385. doi: 10.3389/fgene.2018.00385en_US
dc.identifier.other10.3389/fgene.2018.00385
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8608
dc.language.isoenen_US
dc.publisherFrontiers in Geneticsen_US
dc.subjectLocal adaptationen_US
dc.subjectLandscape genomicsen_US
dc.subjectSpecies distribution modellingen_US
dc.subjectIndigenous cattleen_US
dc.titleCombining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Feveren_US
dc.typeArticleen_US
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