DPPH• Free Radical Scavenging Activity of Coumarin Derivatives. In silico and in vitro Approach

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dc.contributor.authorJorge, Elizabeth Goya
dc.contributor.authorRayar, Anita Maria
dc.contributor.authorBarigye, Stephen Jones
dc.contributor.authorRodríguez, María Elisa Jorge
dc.contributor.authorVeitía, Maite Sylla Iyarreta
dc.date.accessioned2023-02-09T17:02:10Z
dc.date.available2023-02-09T17:02:10Z
dc.date.issued2015
dc.description.abstractThe interest of coumarins as antioxidant agents has attracted much attention in recent years. A quantitative structure-activity relationship (QSAR) study of the DPPH• (2,2-diphenyl-lpicrylhydrazyl) radical scavenging ability of chemical compounds, based on the 0-3D DRAGON molecular descriptors and an artificial neural networks (ANN) technique was developed. The built mathematical model showed a correlation coefficient for the training set (R2) = 0.71, an external correlation coefficient (𝑄𝑒𝑥𝑡 2) = 0.65 and it was used to predict the antioxidant activity of 4-hydroxycoumarin derivatives. Besides, an experimental in vitro assay was developed for the reference compound of this group (4-hydroxycoumarin) and the results obtained confirmed the predictions made by the ANN.en_US
dc.identifier.citationJorge, E. G., Rayar, A. M., Barigye, S. J., & Jorge, M. E. (2015). DPPH• Free Radical Scavenging Activity of Coumarin Derivatives. In silico and in vitro Approach.en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7704
dc.language.isoenen_US
dc.publisherMol2Neten_US
dc.subjectcoumarinen_US
dc.subjectartificial neural networksen_US
dc.subjectantioxidanten_US
dc.subjectQSARen_US
dc.titleDPPH• Free Radical Scavenging Activity of Coumarin Derivatives. In silico and in vitro Approachen_US
dc.typePresentationen_US
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