COVID-19 vaccination status and associated factors among patients presenting with COVID-19-like symptoms in Uganda

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dc.contributor.authorKusemererwa, Sylvia
dc.contributor.authorAnkunda, Violet
dc.contributor.authorOngaria, Terry A.
dc.contributor.authorAbaasa, Andrew
dc.contributor.authorKakande, Ayoub
dc.contributor.authorSsemwanga, Deogratius
dc.contributor.authorKimbugwe, Geofrey
dc.contributor.authorNayiga, Bernadette
dc.contributor.authorBosa, Henry K.
dc.contributor.authorDriwale, Alfred
dc.contributor.authorYonas, T. Woldemariam
dc.contributor.authorKisakye, Annet
dc.contributor.authorJames, Humphreys
dc.contributor.authorArchibald, K. Worwui
dc.contributor.authorSandra, Cohuet
dc.contributor.authorMwenda, Jason M.
dc.contributor.authorAlison, M. Elliott
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorRuzagira, Eugene
dc.date.accessioned2025-04-11T19:46:01Z
dc.date.available2025-04-11T19:46:01Z
dc.date.issued2025
dc.description.abstractThe emergence of new SARS-CoV-2 variants threatens the effectiveness of global vaccination campaigns. This study examines the vaccination status and associated factors among patients presenting with COVID-19-like symptoms at 19 healthcare facilities in Uganda. Materials and methods A cross-sectional analysis was conducted using data collected at health facilities to evaluate the effectiveness of COVID-19 vaccines in Uganda from March 2023 to March 2024. Participants were individuals aged 12 years and older with COVID-19-like symptoms who underwent a SARS-CoV-2 qPCR test within 10 days of symptom onset. The study involved obtaining informed consent, collecting medical and vaccination histories (confirmed using vaccination cards and Ministry of Health COVID-19 database), performing physical examinations, administering a questionnaire, and taking oral/nasopharyngeal swabs for SARS-CoV-2 qPCR testing. Vaccination coverage was defined as receiving at least one vaccine dose. Logistic regression was used to identify factors associated with vaccination status. Results Among 1398 participants enrolled (55.4 % female), the median age was 30.0 years (IQR: 24.0–41.0). Vaccination coverage, was 66.6 %. Residing in Wakiso district compared to the Capital, Kampala was associated with a higher likelihood of vaccination (adjusted odds ratio [aOR] = 1.4, 95 % CI: 1.0–1.8, p = 0.021). Frontline and healthcare workers were more likely to be vaccinated (aOR = 5.0, 95 % CI: 3.6–7.3, p < 0.001), as were individuals with a previous COVID-19 diagnosis (aOR = 2.4, 95 % CI: 1.6–3.9, p < 0.001). Conclusions Our results underscore the need for targeted public health messaging and support to promote vaccination, especially among non-healthcare workers. Addressing these gaps is crucial for maintaining high vaccination coverage and mitigating the impact of new SARS-CoV-2 variants on the population.
dc.identifier.citationKusemererwa, S., Ankunda, V., Ongaria, T. A., Abaasa, A., Kakande, A., Ssemwanga, D., ... & Ruzagira, E. (2025). COVID-19 vaccination status and associated factors among patients presenting with COVID-19-like symptoms in Uganda. Vaccine, 126984.
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2025.126984
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10539
dc.language.isoen
dc.publisherVaccine
dc.titleCOVID-19 vaccination status and associated factors among patients presenting with COVID-19-like symptoms in Uganda
dc.typeArticle
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