Vaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda

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dc.contributor.authorGianella, Sara
dc.contributor.authorRedd, Andrew D.
dc.contributor.authorGrabowski, Mary K.
dc.contributor.authorTobian, Aaron A. R.
dc.contributor.authorSerwadda, David
dc.contributor.authorNewell, Kevin
dc.contributor.authorPatel, Eshan U.
dc.contributor.authorKalibbala, Sarah
dc.contributor.authorSsebbowa, Paschal
dc.contributor.authorGray, Ronald H.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorReynolds, Steven J.
dc.date.accessioned2022-01-20T22:21:01Z
dc.date.available2022-01-20T22:21:01Z
dc.date.issued2015
dc.description.abstractVaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0%) and 379 of 1080 individual visits (35.1%). ART status, higher HIV RNAviral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P < .01). Compared to pre- ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.en_US
dc.identifier.citationGianella, S., Redd, A. D., Grabowski, M. K., Tobian, A. A., Serwadda, D., Newell, K., ... & Reynolds, S. J. (2015). Vaginal cytomegalovirus shedding before and after initiation of antiretroviral therapy in Rakai, Uganda. The Journal of infectious diseases, 212(6), 899-903. DOI: 10.1093/infdis/jiv135en_US
dc.identifier.other10.1093/infdis/jiv135
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1369
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectAcycloviren_US
dc.subjectAntiretroviral therapy (ART)en_US
dc.subjectCytomegalovirus (CMV)en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.subjectImmune reconstitution inflammatory syndrome (IRIS)en_US
dc.subjectReactivationen_US
dc.subjectUgandaen_US
dc.titleVaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Ugandaen_US
dc.typeArticleen_US
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