The Evidence For Using Conjugate Vaccines To Protect HIV-Infected Children Against Pneumococcal Disease
dc.contributor.author | Bliss, Sandra J. | |
dc.contributor.author | O’Brien, Katherine L. | |
dc.contributor.author | Janoff, Edward N. | |
dc.contributor.author | Cotton, Mark F. | |
dc.contributor.author | Musoke, Philippa | |
dc.contributor.author | Coovadia, Hoosen | |
dc.contributor.author | Levine, Orin S. | |
dc.date.accessioned | 2022-01-29T13:19:29Z | |
dc.date.available | 2022-01-29T13:19:29Z | |
dc.date.issued | 2008 | |
dc.description.abstract | Pneumococcal conjugate vaccines (PCVs) are a potentially useful complement to existing treatment strategies in HIV-infected children, for whom pneumococcal infections are common and serious. This Review summarises available data on the burden of pneumococcal disease and the safety and efficacy of PCVs in HIV-infected children. The data demonstrate that children with HIV have significantly increased risk of pneumococcal disease compared with uninfected children; the serotypes included in currently licensed or near-licensure conjugate vaccines include most serotypes that cause invasive pneumococcal disease (IPD) in HIV-infected children and adults; PCVs provide substantial protection against IPD and clinical pneumonia when given to HIV-infected infants; and HIV-infected adults gain an indirect benefit when children in the community are vaccinated. PCV should be considered as an important intervention for improving the lives of HIV-infected children. | en_US |
dc.identifier.citation | Bliss, S. J., O'Brien, K. L., Janoff, E. N., Cotton, M. F., Musoke, P., Coovadia, H., & Levine, O. S. (2008). The evidence for using conjugate vaccines to protect HIV-infected children against pneumococcal disease. The Lancet infectious diseases, 8(1), 67-80.https://doi.org/10.1016/S1473-3099(07)70242-6 | en_US |
dc.identifier.issn | 1473-3099 | |
dc.identifier.uri | https://nru.uncst.go.ug/xmlui/handle/123456789/1614 | |
dc.language.iso | en | en_US |
dc.publisher | The Lancet infectious diseases | en_US |
dc.title | The Evidence For Using Conjugate Vaccines To Protect HIV-Infected Children Against Pneumococcal Disease | en_US |
dc.type | Article | en_US |
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