Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy

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dc.contributor.authorLee, Sulggi
dc.contributor.authorByakwaga, Helen
dc.contributor.authorBoum, Yap
dc.contributor.authorBurdo, Tricia H.
dc.contributor.authorWilliams, Kenneth C.
dc.contributor.authorLederman, Michael M.
dc.contributor.authorHuang, Yong
dc.contributor.authorTracy, Russell P.
dc.contributor.authorCao, Huyen
dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorKembabazi, Annet
dc.contributor.authorBangsberg, David R.
dc.contributor.authorMartin, Jeffrey N.
dc.contributor.authorHunt, Peter W.
dc.date.accessioned2022-01-31T12:39:22Z
dc.date.available2022-01-31T12:39:22Z
dc.date.issued2017
dc.description.abstractThe plasma kynurenine/tryptophan (KT) ratio, a marker of adaptive immune defects, strongly predicts mortality during treated human immunodeficiency virus (HIV) disease in Ugandans as compared to US-based populations. Here, the KT ratio and T-cell and plasma biomarkers of immune activation were measured among 535 HIV-infected Ugandans prior to ART initiation and at month 6 of viral suppression. The month 6 KT ratio (adjusted hazard ratio [aHR], 2.74), soluble CD14 level (aHR, 2.32), interleukin 6 level (aHR, 2.34), and D-dimer level (aHR, 1.95) were associated with mortality occurring ≥6 months after ART initiation. The KT ratio remained significantly predictive of mortality even after adjustment for the additional biomarkers, suggesting an independent contribution to clinical outcomes in resource-limited settings.en_US
dc.identifier.citationLee, S., Byakwaga, H., Boum, Y., Burdo, T. H., Williams, K. C., Lederman, M. M., ... & Hunt, P. W. (2017). Immunologic pathways that predict mortality in HIV-infected Ugandans initiating antiretroviral therapy. The Journal of infectious diseases, 215(8), 1270-1274. DOI: 10.1093/infdis/jix113en_US
dc.identifier.other10.1093/infdis/jix113
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1672
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.subjectHIVen_US
dc.subjectKynurenineen_US
dc.subjectTryptophanen_US
dc.subjectD-dimeren_US
dc.subjectIL-6; sCD14en_US
dc.subjectMortalityen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectAfricaen_US
dc.titleImmunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapyen_US
dc.typeArticleen_US
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