The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configuration

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dc.contributor.authorObara, Isaiah
dc.contributor.authorAtimnedi, Patrick
dc.contributor.authorMijele, Domnic
dc.contributor.authorNanteza, Anne
dc.contributor.authorElati, Khawla
dc.contributor.authorBishop, Richard
dc.date.accessioned2023-03-07T12:39:43Z
dc.date.available2023-03-07T12:39:43Z
dc.date.issued2022
dc.description.abstractAfrican buffalo (Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of multiple pathogens, that affect introduced domestic cattle. To date, there has been no analysis of the class I MHC locus in African buffalo. We present the first data on African buffalo class I MHC, which demonstrates that gene and predicted protein coding sequences are approximately 86–87% similar to that of African domestic cattle in the peptide binding region. The study also shows concordance in the distribution of codons with elevated posterior probabilities of positive selection in the buffalo class I MHC and known antigen binding sites in cattle. Overall, the diversity in buffalo class I sequences appears greater than that in cattle, perhaps related to a more complex pathogen challenge environment in Africa. However, application of NetMHCpan suggested broad clustering of peptide binding specificities between buffalo and cattle. Furthermore, in the case of at least 20 alleles, critical peptide-binding residues appear to be conserved with those of cattle, including at secondary anchor residues. Alleles with six different length transmembrane regions were detected. This preliminary analysis suggests that like cattle, but unlike most other mammals, African buffalo appears to exhibit configuration (haplotype) variation in which the loci are expressed in distinct combinations.en_US
dc.identifier.citationObara, I., Nijhof, A., Atimnedi, P., Mijele, D., Nanteza, A., Elati, K., & Bishop, R. (2022). The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’region suggests distinct haplotype configurations. Immunogenetics, 1-18.https://doi.org/10.1007/s00251-022-01287-0en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8113
dc.language.isoenen_US
dc.publisherImmunogeneticsen_US
dc.subjectAfrican buffalo (Syncerus caffer)en_US
dc.subjectClass I MHCen_US
dc.subjectTheileria parvaen_US
dc.titleThe antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configurationen_US
dc.typeArticleen_US
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