Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997–2007
Loading...
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of vector borne diseases
Abstract
A major characteristic of human malaria parasites is their genetic diversity and an increasing number
of studies have been reported on the epidemiology of Plasmodium falciparum, mainly focusing on
the polymorphism of merozoite surface protein (MSP) 1 and 2 genes. A myriad of information on
the genetic diversity and multiplicity of P. falciparum infections has been generated from such
studies, and a range of molecular tools for epidemiological studies were produced, creating both
optimism and pessimism in regard to the global efforts to control malaria. The objective of this
review is to provide current and comprehensive information on the diversity in the gene that encodes
the merozoite surface protein (MSP) 1 and 2 of P. falciparum and its implications on the epidemiology
of malaria, immunity and development of control measures, and point out some research themes
that need to be explored further by utilizing molecular techniques currently at our disposal. Articles
published in journals between 1997 and 2007 are herein reviewed.
Description
Keywords
Genetic diversity, Immune response, Merozoite surface protein, Multiplicity, Plasmodium falciparum
Citation
Kiwanuka, G. N. (2009). Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997-2007. Journal of vector borne diseases, 46(1), 1.