Analysis of HIV tropism in Ugandan infants
dc.contributor.author | Church, Jessica D. | |
dc.contributor.author | Huang, Wei | |
dc.contributor.author | Mwatha, Anthony | |
dc.contributor.author | Musoke, Philippa | |
dc.contributor.author | Jackson, J. Brooks | |
dc.contributor.author | Bagenda, Danstan | |
dc.contributor.author | Omer, Saad B. | |
dc.contributor.author | Donnell, Deborah | |
dc.contributor.author | Nakabiito, Clemensia | |
dc.contributor.author | Eure, Chineta | |
dc.contributor.author | Guay, Laura A. | |
dc.contributor.author | Taylor, Allan | |
dc.contributor.author | Bakaki, Paul M. | |
dc.contributor.author | Matovu, Flavia | |
dc.contributor.author | McConnell, Michelle | |
dc.contributor.author | Fowler, Mary Glenn | |
dc.contributor.author | Eshleman, Susan H. | |
dc.date.accessioned | 2021-12-15T09:23:16Z | |
dc.date.available | 2021-12-15T09:23:16Z | |
dc.date.issued | 2010 | |
dc.description.abstract | HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV-infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6–8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6–12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5- RLU at 6–8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025). | en_US |
dc.identifier.citation | D Church, Jessica, Wei Huang, Anthony Mwatha, Philippa Musoke, J. Brooks Jackson, Danstan Bagenda, Saad B Omer et al. "Analysis of HIV tropism in Ugandan infants." Current HIV research 8, no. 7 (2010): 498-503. https://doi.org/10.2174/157016210793499187 | en_US |
dc.identifier.uri | https://doi.org/10.2174/157016210793499187 | |
dc.identifier.uri | https://nru.uncst.go.ug/xmlui/handle/123456789/556 | |
dc.language.iso | en | en_US |
dc.publisher | Current HIV research | en_US |
dc.subject | CCR5 | en_US |
dc.subject | CXCR4 | en_US |
dc.subject | HIV-1 | en_US |
dc.subject | Infant | en_US |
dc.subject | Survival | en_US |
dc.subject | Transmission | en_US |
dc.subject | Tropism | en_US |
dc.title | Analysis of HIV tropism in Ugandan infants | en_US |
dc.type | Article | en_US |
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